The Impact of Omega 3 Fatty Acids in Atherosclerosis and Arterial Stiffness: An Overview of their Actions
| Autor: | Gerasimos Siasos, Marina Zaromitidou, Spyridon Deftereos, Manolis Vavuranakis, Nikolaos Papageorgiou, Dimitris Tousoulis, Evangelos Oikonomou, Christodoulos Stefanadis, Georgios Marinos, Theodora Psaltopoulou, Alexios Verveniotis, Athanasios G. Papavassiliou, Vasiliki Tsigkou |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Inflammation 030204 cardiovascular system & hematology Carbohydrate metabolism Pharmacology medicine.disease_cause 03 medical and health sciences 0302 clinical medicine Vascular Stiffness Drug Discovery Fatty Acids Omega-3 medicine Animals Humans Endothelial dysfunction 030109 nutrition & dietetics business.industry medicine.disease Atherosclerosis Eicosapentaenoic acid Review article Docosahexaenoic acid Arterial stiffness medicine.symptom business Oxidative stress |
| Zdroj: | Current pharmaceutical design. 24(17) |
| ISSN: | 1873-4286 |
| Popis: | Background: Fatty acids are common dietary nutrients particularly in economically developed countries. Research has revealed that omega-3fatty acids exert beneficial effects in the progression of atherosclerosis and cardiovascular disease. Moreover, eicosapentaenoic acid and docosahexaenoic acid possess a number of biological actions which improve cardio-metabolic health. Omega-3 fatty acids display remarkable anti-oxidant, anti-inflammatory, anti-thrombotic and anti-arrhythmogenic actions. Furthermore, they improve the levels of triglycerides, glucose metabolism and endothelial function. Methods: The aim of this review article is to present physical, biochemical and biological properties of omega-3 fatty acids and summarize the most important mechanisms of action on arterial wall properties and arterial stiffness in atherosclerosis. Results: Omega-3 fatty acids may prevent the progression of atherosclerosis. Endothelial dysfunction and arterial stiffness can be regulated by the supplementation of omega-3 fatty acids. Conclusion: The mechanisms of action of omega-3 fatty acids on cardiovascular health and arterial stiffening have been established. However, further research is needed in order to translate the conflicting results among the studies and improve the therapeutic options of cardiovascular disease. |
| Databáze: | OpenAIRE |
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