Transforming Growth Factor Beta 1 Overexpression Is Closely Related to Invasiveness of Hepatocellular Carcinoma
| Autor: | Jeong A. Kim, Danbi Lee, Kang Mo Kim, Myoung Kuk Jang, Yung Sang Lee, Yoon Seon Lee, Don Lee, Young-Hwa Chung, Han Chu Lee, Young-Suk Lim |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Cancer Research Carcinoma Hepatocellular Enzyme-Linked Immunosorbent Assay Biology Transforming Growth Factor beta Carcinoma medicine Humans Neoplasm Metastasis Aged Cell Proliferation Aged 80 and over Regulation of gene expression Cell growth Liver Neoplasms Disease progression General Medicine Transforming growth factor beta Middle Aged medicine.disease Gene Expression Regulation Neoplastic Oncology Hepatocellular carcinoma Immunology Disease Progression Cancer research biology.protein Female |
| Zdroj: | Oncology. 82:11-18 |
| ISSN: | 1423-0232 0030-2414 |
| Popis: | Objectives: The study was aimed to investigate the relationship between plasma transforming growth factor beta 1 (TGF-β1) expression and the characteristics of hepatocellular carcinoma (HCC). Methods: Five hundred and seventy-one patients with HCC were subjected. Plasma TGF-β1 levels were measured by enzyme-linked immunosorbent assay at diagnosis and compared in accordance with clinical and radiological characteristics. Results: Plasma TGF-β1 levels were significantly higher in the diffuse infiltrative type (n = 159) than in the nodular type of HCC (n = 412; 3.94 ± 0.34 vs. 3.79 ± 0.29 log10 pg/ml; p < 0.001). They were much higher in patients with portal vein thrombosis or extrahepatic metastasis than in those without (3.88 ± 0.34 vs. 3.81 ± 0.29 log10 pg/ml, p = 0.008; 3.94 ± 0.35 vs. 3.82 ± 0.30 log10 pg/ml, p = 0.013, respectively). Also, plasma TGF-β1 levels showed a positive correlation with the size of HCC (r = 0.014, p < 0.001). Additionally, plasma TGF-β1 levels were inversely related to the survival periods (p < 0.001). Conclusion: TGF-β1 was overexpressed in invasive types of HCC and it may be involved in the rapid progression of HCC. |
| Databáze: | OpenAIRE |
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