Undetectable or low (<1 ng/ml) postsurgical thyroglobulin values do not rule out metastases in early stage differentiated thyroid cancer patients
| Autor: | Salvatore Giovinazzo, Rossella Filice, Riccardo Laudicella, Sergio Baldari, Giuseppe Giuffrida, Maria Elena Stipo, Salvatore Antonio Pignata, Angela Alibrandi, Francesco Trimarchi, Luca Giovanella, Alfredo Campennì, Rosaria Maddalena Ruggeri, Letterio Sturiale, Alessio Danilo Comis, Antonio Vento |
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| Rok vydání: | 2018 |
| Předmět: |
Giovanella
medicine.medical_treatment 131-radioiodine thyroid remnant ablation differentiated thyroid cancer thyroglobulin Diagnostic tools 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine 131-radioiodine treatment medicine In patient Euthyroid Stage (cooking) Thyroid cancer post-therapy whole body scintigraphy Differentiated thyroid cancer Posttherapy whole body scintigraphy Thyroglobulin Oncology business.industry Thyroid medicine.disease medicine.anatomical_structure 030220 oncology & carcinogenesis Nuclear medicine business Research Paper |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| Popis: | // Alfredo Campenni 1 , Luca Giovanella 2 , Salvatore Antonio Pignata 1 , Antonio Vento 1 , Angela Alibrandi 4 , Letterio Sturiale 1 , Riccardo Laudicella 1 , Alessio Danilo Comis 1 , Rossella Filice 1 , Giuseppe Giuffrida 3 , Maria Elena Stipo 1 , Salvatore Giovinazzo 3 , Francesco Trimarchi 5 , Rosaria Maddalena Ruggeri 3 and Sergio Baldari 1 1 Department of Biomedical and Dental Sciences and Morpho-Functional Imaging, Nuclear Medicine Unit, University of Messina, Messina, Italy 2 Nuclear Medicine and PET/CT Centre, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland 3 Department of Clinical and Experimental Medicine, Unit of Endocrinology, University of Messina, Messina, Italy 4 Department of Economical, Business and Environmental Sciences and Quantitative Methods, University of Messina, Messina, Italy 5 Accademia Peloritana dei Pericolanti, University of Messina, Messina, Italy Correspondence to: Alfredo Campenni, email: acampenni@unime.it Keywords: differentiated thyroid cancer; 131-radioiodine treatment; 131-radioiodine thyroid remnant ablation; thyroglobulin; post-therapy whole body scintigraphy Received: December 11, 2017 Accepted: February 26, 2018 Published: April 03, 2018 ABSTRACT Background: Differentiated thyroid cancer (DTC) work-up is based on (near)total-thyroidectomy plus thyroid remnant ablation (TRA) with 131-radioiodine in many patients, and long-life follow-up. 131 I-post therapy whole body scan (pT-WBS) and serum thyroglobulin (Tg) are used in identifying metastatic patients. Some authors have evaluated the possibility of using post-surgical Tg (ps-Tg) values in deciding for or against TRA. The aim of our study was to verify the diagnostic accuracy of 131 I-pT-WBS and SPECT/CT imaging (post-therapeutic imaging) compared to serum Tg levels in detecting metastases in early stage of DTC patients. Results: Post-therapeutic imaging revealed metastases in 82 out of 570 (14.4%) patients. Metastases were successively confirmed by other diagnostic tools or by histology (sensitivity and PPV = 100%). Seventy-three out of 82 patients (90.2%) showed ps-Tg levels ≤1 ng/ml. In fifty-four per cent of patients, serum Tg levels at TRA remained ≤1 ng/ml. Conclusion: In conclusion, ps-Tg levels cannot be used in deciding for or against TRA. In early stage of DTC, post-therapeutic imaging ( 131 I-pT-WBS and SPECT/CT) is an accurate method of detecting metastases, also in patients with stimulated serum Tg values ≤1 ng/ml Methods: We retrospectively reviewed the records of 570 consecutive patients affected by pT1-pT3 DTC (F = 450, M = 120), referred to our Nuclear Medicine Units in the last five years to perform TRA after (near)-total-thyroidectomy.All patients underwent TRA 3-4 months after thyroid surgery either in euthyroid or in hypothyroid state. Serum Tg values evaluated in post-surgical period and at TRA were matched with post-therapeutic imaging results. |
| Databáze: | OpenAIRE |
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