Comparative analysis of calcification parameters with Agatston Score approximations for ex vivo atherosclerotic lesions
| Autor: | Michael Walsh, Julie M. O'Brien, Rachel M. Cahalane, Rosaire Mongrain, Michael A. Moloney, Stephen P. Broderick, Eamon G. Kavanagh, Helen Purtill |
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| Rok vydání: | 2020 |
| Předmět: |
Carotid Artery Diseases
Male medicine.medical_specialty 030204 cardiovascular system & hematology Positive correlation Severity of Illness Index 030218 nuclear medicine & medical imaging Peripheral Arterial Disease 03 medical and health sciences 0302 clinical medicine Predictive Value of Tests Internal medicine Hounsfield scale Humans Medicine Radiology Nuclear Medicine and imaging Vascular Calcification Aged Rupture Spontaneous business.industry Reproducibility of Results X-Ray Microtomography Middle Aged Prognosis medicine.disease Tailored treatment Plaque Atherosclerotic Lower Extremity Calcium scoring Cardiology Radiographic Image Interpretation Computer-Assisted Female Cardiology and Cardiovascular Medicine business Agatston score Calcium score Ex vivo Calcification |
| Zdroj: | Journal of Cardiovascular Computed Tomography. 14:20-26 |
| ISSN: | 1934-5925 |
| Popis: | The Agatston Calcium Score is a predictor of major adverse cardiovascular events but it is unable to identify high-risk lesions. Recent research suggests that examining calcification phenotype could be more indicative of plaque stability.To examine the Agatston score's ability to determine atherosclerotic calcification phenotype.Micro-Computed Tomography was performed on 20 carotid and 20 peripheral lower limb lesions. ImageJ pixel histogram analysis quantified the non-calcified (≥30HU,130HU) and calcified (≥130HU) tissue volumes. ImageJ '3D Objects Counter' plugin determined the calcified particle count, volumes and maximum attenuation density of each particle. Image stacks were subsequently downsampled to a resolution of 0.7 × 0.7 × 3 mm and an approximation for the Extra-Coronary Calcium Scores (ECCS) were calculated. Spearman's correlation examined the relationships between ECCS approximations and calcification parameters.ECCS has a strong positive correlation with the Calcified Volume Fraction (CVF) (rThe density-weighted Agatston calcium scoring methodology needs to be reviewed. Calcium scoring which differentiates between critical calcification morphologies, rather than presenting a density-weighted score, is required to direct high-risk plaques towards tailored treatment. |
| Databáze: | OpenAIRE |
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