Elevated serum levels of soluble tumour necrosis factor receptors (sTNF-R) in patients with HIV infection
| Autor: | I Kalickman, N Harpaz, R Burstein, V Barak, David Wallach, Zvi Bentwich, A Kalinkovich, H Engelmann |
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| Rok vydání: | 1992 |
| Předmět: |
Male
Necrosis Immunology Enzyme-Linked Immunosorbent Assay HIV Infections Receptors Cell Surface Homosexuality Biology medicine.disease Asymptomatic Receptors Tumor Necrosis Factor Pathogenesis Solubility Acquired immunodeficiency syndrome (AIDS) Immunopathology HIV Seropositivity medicine Humans Immunology and Allergy Tumor necrosis factor alpha Seroconversion medicine.symptom Receptor Research Article |
| Zdroj: | Clinical and Experimental Immunology. 89:351-355 |
| ISSN: | 1365-2249 0009-9104 |
| Popis: | SUMMARY Serum levels of the soluble form of tumour necrosis factor receptor type II (p75) (sTNF-R) were determined in HIV-infected individuals and risk groups and were then correlated with the course of infection and prognosis. sTNF-R levels were determined by an ELISA with MoAbs and polyclonal antibodies to urine-derived sTNF-R proteins. The mean ±s.e. levels of sTNF-R in the sera of 49 HIV+ male homosexuals, 34 HIV− male homosexuals and 44 matched controls were 6·1 ± 0·3 ng/ml, 4·4 ± 0·3 ng/ml and 3·4 ± 0·2 ng/ml, respectively. All these values were significantly different between each of the groups (P < 0·001–0·05). Sequential studies of sTNF-R revealed higher levels following seroconversion in 5/8 individuals, remained persistently high during the asymptomatic phase of the infection and became even more elevated in some ARC and AIDS patients. At the same time TNF-α was undetectable in sera obtained from HIV+ male homosexuals and from healthy controls. This was independent of stage of HIV infection, serum sTNF-R level and type of ELISA kit used. These findings suggest that TNF-α/TNF-R system is turned on before and during HIV infection and raise the possibility that sTNF-R, the natural inhibitor of TNF, may be of importance in determining the course and probably prognosis of the disease. |
| Databáze: | OpenAIRE |
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