Adsorption of Multimeric T Cell Antigens on Carbon Nanotubes: Effect on Protein Structure and Antigen-Specific T Cell Stimulation
| Autor: | Tarek M. Fahmy, Sune Justesen, Nan Li, Michael Look, Tarek R. Fadel, Lisa D. Pfefferle, Gary L. Haller, Corey J. Wilson, Smith Shah |
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| Rok vydání: | 2012 |
| Předmět: |
Materials science
T-Lymphocytes T cell Carbon nanotube law.invention Biomaterials Mice Adsorption Protein structure Antigen Biomimetics law medicine Animals Cytotoxic T cell General Materials Science Antigens biology Nanotubes Carbon Circular Dichroism NeutrAvidin General Chemistry medicine.anatomical_structure Biochemistry biology.protein Biophysics Linker Biotechnology |
| Zdroj: | Small. 9:666-672 |
| ISSN: | 1613-6810 |
| DOI: | 10.1002/smll.201201684 |
| Popis: | Antigen-specific activation of cytotoxic T cells can be enhanced up to three-fold more than soluble controls when using functionalized bundled carbon nanotube substrates ((b) CNTs). To overcome the denaturing effects of direct adsorption on (b) CNTs, a simple but robust method is demonstrated to stabilize the T cell stimulus on carbon nanotube substrates through non-covalent attachment of the linker neutravidin. |
| Databáze: | OpenAIRE |
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