High level of vector competence of Aedes aegypti and Aedes albopictus from ten American countries as a crucial factor in the spread of Chikungunya virus
| Autor: | Ricardo Lourenço-de-Oliveira, Anna-Bella Failloux, Romain Girod, Karima Zouache, Anubis Vega-Rúa |
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| Přispěvatelé: | Cellule Pasteur UPMC, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut Pasteur [Paris] (IP), Arbovirus et Insectes Vecteurs - Arboviruses and Insect Vectors, Institut Pasteur [Paris] (IP), Institut Pasteur de la Guyane, Réseau International des Instituts Pasteur (RIIP), Fundação Oswaldo Cruz / Oswaldo Cruz Foundation (FIOCRUZ), This work was funded by CNPq (grants 202106/2011-0 and 306340/2009-7), Instituto Oswaldo Cruz, Institut Pasteur (ACIP grant A-03-2012), and the French Government's Investissement d'Avenir program, Laboratoire d'Excellence 'Integrative Biology of Emerging Infectious Diseases' (grant no. ANR-10-LABX-62-IBEID). A.V.-R. was supported by the French Ministry of Superior Education and Research and K.Z. by the European Community's Seventh Framework Programme (FP7/2007-2 013) under the project 'VECTORIE,' EC grant agreement no. 261466, and the Foundation Inkermann (Fondation de France)., ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010), European Project: 261466,EC:FP7:HEALTH,FP7-HEALTH-2010-single-stage,VECTORIE(2010), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut Pasteur [Paris], Institut Pasteur [Paris], Fundação Oswaldo Cruz (FIOCRUZ) |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Aedes albopictus
viruses MESH: Insect Vectors/virology Immunology Aedes aegypti MESH: Chikungunya Fever medicine.disease_cause Microbiology Virus Statistics Nonparametric Dengue fever MESH: Saliva/virology Species Specificity Aedes Virology medicine Animals MESH: Americas MESH: Species Specificity MESH: Animals Chikungunya MESH: Alphavirus Infections/transmission Alphavirus infection Saliva MESH: Chikungunya virus/genetics MESH: Statistics Nonparametric biology MESH: Aedes/virology Alphavirus Infections fungi Outbreak virus diseases biology.organism_classification medicine.disease 3. Good health Insect Vectors Genetic Diversity and Evolution Insect Science Vector (epidemiology) [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology Chikungunya Fever Americas Chikungunya virus |
| Zdroj: | Journal of Virology Journal of Virology, 2014, 88 (11), pp.6294-306. ⟨10.1128/JVI.00370-14⟩ Journal of Virology, American Society for Microbiology, 2014, 88 (11), pp.6294-306. ⟨10.1128/JVI.00370-14⟩ |
| ISSN: | 0022-538X 1098-5514 |
| DOI: | 10.1128/JVI.00370-14⟩ |
| Popis: | Chikungunya virus (CHIKV) causes a major public health problem. In 2004, CHIKV began an unprecedented global expansion and has been responsible for epidemics in Africa, Asia, islands in the Indian Ocean region, and surprisingly, in temperate regions, such as Europe. Intriguingly, no local transmission of chikungunya virus (CHIKV) had been reported in the Americas until recently, despite the presence of vectors and annually reported imported cases. Here, we assessed the vector competence of 35 American Aedes aegypti and Aedes albopictus mosquito populations for three CHIKV genotypes. We also compared the number of viral particles of different CHIKV strains in mosquito saliva at two different times postinfection. Primarily, viral dissemination rates were high for all mosquito populations irrespective of the tested CHIKV isolate. In contrast, differences in transmission efficiency (TE) were underlined in populations of both species through the Americas, suggesting the role of salivary glands in selecting CHIKV for highly efficient transmission. Nonetheless, both mosquito species were capable of transmitting all three CHIKV genotypes, and TE reached alarming rates as high as 83.3% and 96.7% in A. aegypti and A. albopictus populations, respectively. A. albopictus better transmitted the epidemic mutant strain CHIKV_0621 of the East-Central-South African (ECSA) genotype than did A. aegypti , whereas the latter species was more capable of transmitting the original ECSA CHIKV_115 strain and also the Asian genotype CHIKV_NC. Therefore, a high risk of establishment and spread of CHIKV throughout the tropical, subtropical, and even temperate regions of the Americas is more real than ever. IMPORTANCE Until recently, the Americas had never reported chikungunya (CHIK) autochthonous transmission despite its global expansion beginning in 2004. Large regions of the continent are highly infested with Aedes aegypti and Aedes albopictus mosquitoes, and millions of dengue (DEN) cases are annually recorded. Indeed, DEN virus and CHIK virus (CHIKV) share the same vectors. Due to a recent CHIK outbreak affecting Caribbean islands, the need for a Pan-American evaluation of vector competence was compelling as a key parameter in assessing the epidemic risk. We demonstrated for the first time that A. aegypti and A. albopictus populations throughout the continent are highly competent to transmit CHIK irrespective of the viral genotypes tested. The risk of CHIK spreading throughout the tropical, subtropical, and even temperate regions of the Americas is more than ever a reality. In light of our results, local authorities should immediately pursue and reinforce epidemiological and entomological surveillance to avoid a severe epidemic. |
| Databáze: | OpenAIRE |
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