Both H4K20 mono-methylation and H3K56 acetylation mark transcription-dependent histone turnover in fission yeast
| Autor: | Hanna Yang, Chang Seob Kwon, Yoonjung Choi, Daeyoup Lee |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Saccharomyces cerevisiae Proteins Transcription Genetic Genes Fungal Biophysics Saccharomyces cerevisiae Biology Methylation Biochemistry Histone Deacetylases Histones 03 medical and health sciences 0302 clinical medicine Histone H1 Schizosaccharomyces Histone methylation Histone H2A Histone code Histone octamer Promoter Regions Genetic Molecular Biology Terminator Regions Genetic Histone deacetylase 2 Chromosome Mapping Acetylation Histone-Lysine N-Methyltransferase Cell Biology Nucleosomes 030104 developmental biology Histone methyltransferase Mutation Histone deacetylase complex Schizosaccharomyces pombe Proteins 030217 neurology & neurosurgery |
| Zdroj: | Biochemical and Biophysical Research Communications. 476:515-521 |
| ISSN: | 0006-291X |
| DOI: | 10.1016/j.bbrc.2016.05.155 |
| Popis: | Nucleosome dynamics facilitated by histone turnover is required for transcription as well as DNA replication and repair. Histone turnover is often associated with various histone modifications such as H3K56 acetylation (H3K56Ac), H3K36 methylation (H3K36me), and H4K20 methylation (H4K20me). In order to correlate histone modifications and transcription-dependent histone turnover, we performed genome wide analyses for euchromatic regions in G2/M-arrested fission yeast. The results show that transcription-dependent histone turnover at 5' promoter and 3' termination regions is directly correlated with the occurrence of H3K56Ac and H4K20 mono-methylation (H4K20me1) in actively transcribed genes. Furthermore, the increase of H3K56Ac and H4K20me1 and antisense RNA production was observed in the absence of the histone H3K36 methyltransferase Set2 and histone deacetylase complex (HDAC) that are involved in the suppression of histone turnover within the coding regions. These results together indicate that H4K20me1 as well as H3K56Ac are bona fide marks for transcription-dependent histone turnover in fission yeast. |
| Databáze: | OpenAIRE |
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