Autologous bone marrow-derived mononuclear cell therapy in three patients with severe asthma
| Autor: | Maria Carolina P. P. Landesmann, Lanuza A. P. Faccioli, Fernanda F. Cruz, José Roberto Lapa e Silva, Bianca Gutfilen, André Cristiano da Silva Melo, Marcelo M. Morales, Sergio Augusto Lopes de Souza, Ana Araújo, Alexandre Pinto Cardoso, Regina Coeli Dos Santos Goldenberg, Fábio Silva Aguiar, Patricia R. M. Rocco, Karina D. Asensi, Debora G. Xisto, Anna Beatriz Salgado, Miquéias Lopes-Pacheco |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Autologous transplantation
medicine.medical_specialty Combination therapy Medicine (miscellaneous) Omalizumab Biochemistry Genetics and Molecular Biology (miscellaneous) Cell therapy Pulmonary function testing lcsh:Biochemistry Adrenal Cortex Hormones Bone Marrow Internal medicine medicine Humans lcsh:QD415-436 Adverse effect Lung Bone Marrow Transplantation Asthma lcsh:R5-920 business.industry Research Cell Biology medicine.disease Transplantation medicine.anatomical_structure Quality of Life Bone marrow mononuclear cells Molecular Medicine lcsh:Medicine (General) business medicine.drug |
| Zdroj: | Stem Cell Research & Therapy Stem Cell Research & Therapy, Vol 11, Iss 1, Pp 1-9 (2020) |
| ISSN: | 1757-6512 |
| DOI: | 10.1186/s13287-020-01675-x |
| Popis: | Background Despite recent advances in understanding its pathophysiology and development of novel therapies, asthma remains a serious public health issue worldwide. Combination therapy with inhaled corticosteroids and long-acting β2-adrenoceptor agonists results in disease control for many patients, but those who exhibit severe asthma are often unresponsive to conventional treatment, experiencing worse quality of life, frequent exacerbations, and increasing healthcare costs. Bone marrow-derived mononuclear cell (BMMC) transplantation has been shown to reduce airway inflammation and remodeling and improve lung function in experimental models of allergic asthma. Methods This is a case series of three patients who presented severe asthma, unresponsive to conventional therapy and omalizumab. They received a single intravenous dose of autologous BMMCs (2 × 107) and were periodically evaluated for 1 year after the procedure. Endpoint assessments included physical examination, quality of life questionnaires, imaging (computed tomography, single-photon emission computed tomography, and ventilation/perfusion scan), lung function tests, and a 6-min walk test. Results All patients completed the follow-up protocol. No serious adverse events attributable to BMMC transplantation were observed during or after the procedure. Lung function remained stable throughout. A slight increase in ventilation of the right lung was observed on day 120 after BMMC transplantation in one patient. All three patients reported improvement in quality of life in the early post-procedure course. Conclusions This paper described for the first time the effects of BMMC therapy in patients with severe asthma, providing a basis for subsequent trials to assess the efficacy of this therapy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink