Age at onset of non-affective psychosis in relation to cannabis use, other drug use and gender
| Autor: | N, Dekker, J, Meijer, M, Koeter, W, van den Brink, N, van Beveren, R S, Kahn, D H, Linszen, J, van Os, D, Wiersma, R, Bruggeman, W, Cahn, L, de Haan, L, Krabbendam, I, Myin-Germeys |
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| Přispěvatelé: | Amsterdam Neuroscience, Adult Psychiatry, Amsterdam Gastroenterology Endocrinology Metabolism, Cancer Center Amsterdam, Laboratory Genetic Metabolic Diseases, Amsterdam Public Health, Psychiatrie & Neuropsychologie, RS: MHeNs School for Mental Health and Neuroscience, Psychiatry, Perceptual and Cognitive Neuroscience (PCN), Educational Neuroscience, LEARN! - Brain, learning and development |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Drug Psychosis medicine.medical_specialty SEX-DIFFERENCES SYMPTOMS Substance-Related Disorders IMPACT media_common.quotation_subject illness-onset substance use Marijuana Smoking Cohort Studies Sex Factors USE DISORDERS medicine gender Humans psychosis Age of Onset Psychiatry ABUSE Applied Psychology media_common Cannabis biology Confounding PSYCHOPATHOLOGY Precipitating Factors medicine.disease biology.organism_classification schizophrenia Psychiatry and Mental health Psychotic Disorders Schizophrenia Regression Analysis Female Age of onset Psychology FOLLOW-UP OF-ONSET Cohort study Psychopathology Clinical psychology |
| Zdroj: | Psychological medicine, 42(9), 1903-1911. Cambridge University Press Psychological Medicine, 42(9), 1903-1911. Cambridge University Press Dekker, N, Meijer, J, Koeter, M W J, van den Brink, W, van Beveren, N, Kahn, R S, Linszen, D H, van Os, J, Wiersma, D, Bruggeman, R, Cahn, W, de Haan, L, Krabbendam, L & Myin-Germeys, I 2012, ' Age at onset of non-affective psychosis in relation to cannabis use, other drug use and gender ', Psychological Medicine, vol. 42, no. 9 . https://doi.org/10.1017/S0033291712000062 Psychological Medicine, 42(9). Cambridge University Press |
| ISSN: | 1469-8978 0033-2917 |
| DOI: | 10.1017/S0033291712000062 |
| Popis: | BackgroundCannabis use is associated with an earlier age at onset of psychotic illness. The aim of the present study was to examine whether this association is confounded by gender or other substance use in a large cohort of patients with a non-affective psychotic disorder.MethodIn 785 patients with a non-affective psychotic disorder, regression analysis was used to investigate the independent effects of gender, cannabis use and other drug use on age at onset of first psychosis.ResultsAge at onset was 1.8 years earlier in cannabis users compared to non-users, controlling for gender and other possible confounders. Use of other drugs did not have an additional effect on age at onset when cannabis use was taken into account. In 63.5% of cannabis-using patients, age at most intense cannabis use preceded the age at onset of first psychosis. In males, the mean age at onset was 1.3 years lower than in females, controlling for cannabis use and other confounders.ConclusionsCannabis use and gender are independently associated with an earlier onset of psychotic illness. Our findings also suggest that cannabis use may precipitate psychosis. More research is needed to clarify the neurobiological factors that make people vulnerable to this precipitating effect of cannabis. |
| Databáze: | OpenAIRE |
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