Indirect cardiac effects of indole, simple indole derivatives, and harmine
| Autor: | G. Zetler |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
Male
Indoles Reserpine Time Factors Pyridines Guinea Pigs Tyramine Stimulation Hexamethonium Compounds Propranolol In Vitro Techniques Tachyphylaxis Pharmacology Hydroxylation Norepinephrine Structure-Activity Relationship chemistry.chemical_compound Alkaloids Harmine Cocaine medicine Animals Heart Atria Indole test Dose-Response Relationship Drug Chemistry Heart General Medicine Electric Stimulation Stimulation Chemical Hexamethonium medicine.drug |
| Zdroj: | Naunyn-Schmiedeberg's Archives of Pharmacology. 283:165-179 |
| ISSN: | 1432-1912 0028-1298 |
| Popis: | 1. Indole, 3-methylindole, 5-methylindole, 5-hydroxyindole, 6-methoxyindole, and harmine produced positive inotropic effects in isolated left guinea-pig atria electrically driven at 1/sec. 2. These actions were antagonized by propranolol and pretreatment with reserpine. In atria of reserpine-pretreated animals, treatment with noradrenaline restored only the effects of tyramine, 3-methylindole, and 5-hydroxyindole. Cocaine reduced the effects of tyramine, 3-methylindole, 5-hydroxyindole, and harmine. Hexamethonium antagonized only the effects of 5-hydroxyindole, 6-methoxyindole, and harmine. 3. Tachyphylaxis developed more quickly for the indoles than for tyramine. Repletion of noradrenaline stores abolished the tachyphylaxis for 5-hydroxyindole, 6-methoxyindole, and harmine but not for indole, 3-methylindole, and 5-methylindole. 4. When the rate of stimulation was increased from 1/sec to 3/sec, the rate of approach to a steady-state response was unaltered for 5-hydroxyindole, decreased for 3-methylindole and harmine, and increased for tyrmaine, indole, 5-methylindole, and 6-methoxyindole. However, the effect of harmine was now negative inotropic. 5. It is concluded that these indole derivatives stimulate the heart muscle by releasing noradrenaline, but their properties differ from those of tyramine. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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