MFG-E8, a clearance glycoprotein of apoptotic cells, as a new marker of disease severity in chronic obstructive pulmonary disease

Autor: Na Hu, J.L. Li, Tianpen Cui, S. Zhang, Bintao Su, Jungang Xie, Guangwei Luo, Jie Chen
Jazyk: angličtina
Rok vydání: 2015
Předmět:
Male
Medicine (General)
Physiology
Interleukin-1beta
Apoptosis
Biochemistry
Gastroenterology
Severity of Illness Index
Apoptotic cell clearance
Pulmonary Disease
Chronic Obstructive
Epidermal growth factor
Transforming Growth Factor beta
Forced Expiratory Volume
Medicine
Biology (General)
General Pharmacology
Toxicology and Pharmaceutics
lcsh:QH301-705.5
Aged
80 and over
COPD
lcsh:R5-920
biology
General Neuroscience
Smoking
Interleukin
Confounding Factors
Epidemiologic
General Medicine
Middle Aged
Milk Proteins
Obstructive lung disease
Antigens
Surface
Regression Analysis
Female
lcsh:Medicine (General)
medicine.medical_specialty
QH301-705.5
Immunology
Biophysics
Ocean Engineering
Enzyme-Linked Immunosorbent Assay
MFG-E8
R5-920
Phagocytosis
Predictive Value of Tests
Internal medicine
Severity of illness
Humans
Clinical Investigation
Aged
business.industry
Case-control study
Cell Biology
Transforming growth factor beta
medicine.disease
ROC Curve
lcsh:Biology (General)
Case-Control Studies
biology.protein
business
Biomarkers
Zdroj: Brazilian Journal of Medical and Biological Research, Vol 48, Iss 11, Pp 1032-1038 (2015)
Brazilian Journal of Medical and Biological Research
Brazilian Journal of Medical and Biological Research, Volume: 48, Issue: 11, Pages: 1032-1038, Published: 08 SEP 2015
Brazilian Journal of Medical and Biological Research v.48 n.11 2015
Associação Brasileira de Divulgação Científica (ABDC)
instacron:ABDC
Popis: Milk fat globule epidermal growth factor 8 (MFG-E8) is an opsonin involved in the phagocytosis of apoptotic cells. In patients with chronic obstructive pulmonary disease (COPD), apoptotic cell clearance is defective. However, whether aberrant MFG-E8 expression is involved in this defect is unknown. In this study, we examined the expression of MFG-E8 in COPD patients. MFG-E8, interleukin (IL)-1β and transforming growth factor (TGF)-β levels were measured in the plasma of 96 COPD patients (93 males, 3 females; age range: 62.12±10.39) and 87 age-matched healthy controls (85 males, 2 females; age range: 64.81±10.11 years) using an enzyme-linked immunosorbent assay. Compared with controls, COPD patients had a significantly lower plasma MFG-E8 levels (P
Databáze: OpenAIRE
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