Efficacy of single or paired intrastromal corneal ring segment implantation combined with collagen crosslinking in keratoconus
Autor: | Alejandro Lichtinger, Stephanie A.W. Low, Sonia N. Yeung, Judy Y.F. Ku, David S. Rootman, Peter Kim |
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Rok vydání: | 2013 |
Předmět: |
Adult
Male medicine.medical_specialty Keratoconus Refractive error Visual acuity genetic structures Ultraviolet Rays Corneal Stroma Riboflavin animal diseases medicine.medical_treatment Visual Acuity law.invention Prosthesis Implantation law Ophthalmology Cornea Humans Medicine Dioptre Retrospective Studies Photosensitizing Agents medicine.diagnostic_test Intrastromal corneal ring segment Keratometer business.industry Corneal Topography virus diseases Prostheses and Implants Prognosis Corneal topography medicine.disease Combined Modality Therapy eye diseases Sensory Systems Surgery Cross-Linking Reagents medicine.anatomical_structure Photochemotherapy Female Collagen medicine.symptom business |
Zdroj: | Journal of Cataract and Refractive Surgery. 39:1146-1151 |
ISSN: | 0886-3350 |
Popis: | Purpose To evaluate the efficacy of single or paired intrastromal corneal ring segments (ICRS) combined with ultraviolet-A and riboflavin collagen crosslinking (CXL) in patients with keratoconus. Setting Cornea Unit, Toronto Western Hospital, Toronto, Ontario, Canada. Design Retrospective comparative case series. Methods Consecutive patients with keratoconus had femtosecond laser–assisted ICRS implantation combined with same-day CXL between 2008 and 2011. The main outcome measures included improvement in visual acuity, subjective refractive error, keratometry values, and total higher-order aberration (HOA). Results Eighty-five eyes of 74 patients with keratoconus (paired ICRS: 47 eyes of 40 patients; single ICRS: 38 eyes of 34 patients) were included in the study. The uncorrected distance visual acuity was significantly improved after single ICRS (3.4 lines; P =.04) and paired ICRS (2.7 lines; P =.01) implantation combined with CXL, while corrected distance visual acuity (CDVA) remained stable. The single and paired ICRS groups had a significant reduction in mean cylinder at 1 year (single ICRS: −3.84 diopters [D] ± 1.72 [SD] versus −2.19 ± 1.54 D, P =.02; paired ICRS: −3.91 ± 1.45 D versus −2.96 ± 1.92 D) ( P =.02). There was no significant difference in total HOAs. Single ICRS implantation and paired ICRS implantation with CXL were equivalent in all refractive parameters. No patient lost lines of CDVA. Conclusion As determined by corneal topography, implantation of single or paired ICRS combined with same-day CXL was safe and effective in patients with keratoconus. Financial Disclosure No author has a financial or proprietary interest in any material or method mentioned. |
Databáze: | OpenAIRE |
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