Head and neck cancer patients under (chemo-)radiotherapy undergoing nutritional intervention: Results from the prospective randomized HEADNUT-trial
| Autor: | Tessa Lorenz, Anastassia Löser, Gesa Matnjani, Julia von Grundherr, M. Sommer, J. Abel, F. Greinert, Cedric Oliver Carl, Luisa Wegert, Loreen Lehmann, Eva Culmann, Rudolf Schwarz, Andreas Krüll, Laura Magdalena Kutz, Anna Finger, Sophie Brackrock, Cordula Petersen, Linda Krause |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Nutritional Status 030218 nuclear medicine & medical imaging law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law Internal medicine Intervention (counseling) medicine Humans Radiology Nuclear Medicine and imaging Prospective Studies Chemo-radiotherapy business.industry Head and neck cancer Malnutrition Hematology medicine.disease Clinical trial Radiation therapy Oncology Head and Neck Neoplasms 030220 oncology & carcinogenesis Carcinoma Squamous Cell business Bioelectrical impedance analysis |
| Zdroj: | Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. 159 |
| ISSN: | 1879-0887 |
| Popis: | Purpose/objective Patients with squamous cell carcinoma of the head and neck undergoing (chemo-)radiotherapy are at high risk of malnutrition. Nevertheless, there is still a lack of prospective, randomized trials investigating the influence of nutritional status on therapy-related toxicity and patients’ outcome. Materials and methods Between October 2018 and October 2020, 61 patients were randomized into an intervention and control group. Questionnaires (MUST, NRS-2002, and Nutriscore), clinical examinations, laboratory analyses, and bioelectrical impedance analysis (BIA) were used to assess nutritional status for all patients at the beginning and end of therapy as well as every 2 weeks during therapy. The intervention consisted of an individualized nutritional counseling every 2 weeks during therapy. Results Median baseline BMI for all participants was 23.8 (14.5–37.2) kg/m2 and dropped to 22.9 (16.8–33) kg/m2 after therapy (p Conclusions Malnutrition negatively impacts patients’ outcome under (chemo-)radiotherapy. Baseline phase angle, posttherapeutic FFMI and albumin level are proposed as reliable indicators for overall survival. This study was registered within the German Clinical Trials Register (DRKS00016862). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect