Reduced cholinergic basal forebrain integrity links neonatal complications and adult cognitive deficits after premature birth

Autor: Peter Bartmann, Chun Meng, Dieter Wolke, Marcel Daamen, Henning Boecker, Stefan J. Teipel, Lukas Scheef, Nicole Baumann, Claus Zimmer, Afra M. Wohlschläger, Michel J. Grothe, Christian Sorg, Josef Bäuml
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Adult
Male
0301 basic medicine
medicine.medical_specialty
diagnostic imaging [Basal Forebrain]
epidemiology [Cognitive Dysfunction]
physiopathology [Cognitive Dysfunction]
Basal Forebrain
pathology [Basal Forebrain]
Intelligence
epidemiology [Germany]
BF
Infant
Premature
Diseases
physiology [Intelligence]
Article
White matter
03 medical and health sciences
0302 clinical medicine
Germany
Internal medicine
medicine
Humans
Cognitive Dysfunction
ddc:610
Adverse effect
Biological Psychiatry
Basal forebrain
epidemiology [Infant
Premature
Diseases]
Cognition
medicine.disease
Magnetic Resonance Imaging
Low birth weight
030104 developmental biology
medicine.anatomical_structure
Infant
Extremely Low Birth Weight
Premature birth
Infant
Extremely Premature
Anesthesia
Cardiology
RC0321
Cholinergic
Female
medicine.symptom
Psychology
Neurocognitive
030217 neurology & neurosurgery
Follow-Up Studies
Zdroj: Biological psychiatry 82(2), 119-126 (2017). doi:10.1016/j.biopsych.2016.12.008
ISSN: 0006-3223
DOI: 10.1016/j.biopsych.2016.12.008
Popis: Background\ud \ud Premature-born individuals have an increased risk for long-term neurocognitive impairments. In animal models, the development of the cholinergic basal forebrain (cBF) is selectively vulnerable to adverse effects of perinatal stressors, and impaired cBF integrity results in lasting cognitive deficits. We hypothesized that in premature-born individuals cBF integrity is impaired and mediates adult cognitive impairments associated with prematurity.\ud \ud Methods\ud \ud We used MRI-based volumetric assessments of a cytoarchitectonically defined cBF region-of-interest to determine differences in cBF integrity between 99 adults who were born very preterm and/or with very low birth weight (VP/VLBW) and 106 term born controls from the same birth cohort. MRI-derived cBF volumes were studied in relation to neonatal clinical complications after delivery as well as intelligence measures (IQ) in adulthood.\ud \ud Results\ud \ud In VP/VLBW adults, cBF volumes were significantly reduced compared to term-born adults (-4.5%, F(1, 202) = 11.82, p = 0.001). Lower cBF volume in VP/VLBW adults was specifically associated with both neonatal complications (rpart(92) = -0.35, p < 0.001) and adult IQ (rpart(88) = 0.33, p = 0.001) even after controlling for global gray matter and white matter volume. In an additional path analytic model, cBF volume significantly mediated the association between neonatal complications and adult cognitive deficits.\ud \ud Conclusions\ud \ud Results provide first time evidence in humans that cBF integrity is impaired after premature birth and links neonatal complications with long-term cognitive outcome. Data suggest that cholinergic system abnormalities may play a relevant role for long-term neurocognitive impairments associated with premature delivery.
Databáze: OpenAIRE
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