Effect of Prolonged GnRH Agonist Downregulation on ICSI Outcome in Patients With Endometriomas of Less Than 5 cm: A Randomized Controlled Trial
| Autor: | Mona Farouk, Akmal El-Mazny, Hamsa Rashwan, Maryam Mahmoud, Doaa S. Belal, Heba Marie, Ahmed M. Maged |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
0301 basic medicine Agonist endocrine system medicine.medical_specialty Pregnancy Rate medicine.drug_class medicine.medical_treatment Endometriosis Reproductive medicine Down-Regulation Oocyte Retrieval Gonadotropin-releasing hormone law.invention Gonadotropin-Releasing Hormone 03 medical and health sciences 0302 clinical medicine Downregulation and upregulation Randomized controlled trial Pregnancy law Internal medicine medicine Humans In patient Sperm Injections Intracytoplasmic Triptorelin Pamoate 030219 obstetrics & reproductive medicine In vitro fertilisation business.industry Pregnancy Outcome Obstetrics and Gynecology Embryo Transfer Treatment Outcome 030104 developmental biology Endocrinology Female business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Reproductive Sciences. 25:1509-1514 |
| ISSN: | 1933-7205 1933-7191 |
| Popis: | To evaluate the effect of prolonged Gonadotropin releasing hormone (GnRH) agonist downregulation in patients with endometriomas of less than 5 cm on the outcome of the proceeding Intracytoplasmic sperm injection (ICSI) trial.In a randomized controlled trial at a university teaching hospital, 90 patients indicated for ICSI and having unilateral single endometrioma of less than 5 cm in diameter were randomized into 2 groups. Group A (45 patients) received the standard long protocol; whereas group B (45 patients) received 3 consecutive Intramuscular (IM) injections of triptorelin 3.75 mg 28 days apart followed by the standard long protocol 28 days after the last injection.There were no significant differences in the clinical and hormonal characteristics between the 2 groups. All ICSI cycle characteristics including number of retrieved oocytes, fertilized oocytes, and transferred embryos were also not significantly different. However, patients who received prolonged GnRH agonist therapy showed significantly higher chemical ( P = .011), clinical ( P = .018), and ongoing ( P = .028) pregnancy rates.Prolonged GnRH agonist downregulation improves the pregnancy rates in patients with small endometriomas undergoing ICSI. |
| Databáze: | OpenAIRE |
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