Extending the analysis of zebrafish behavioral endophenotypes for modeling psychiatric disorders: Fear conditioning to conspecific alarm response
| Autor: | Flavia V. Stefanello, Denis B. Rosemberg, Caio Maximino, Alessandro de Souza Prestes, Cibele B. Batista, Monica Gomes Lima, Maribel Antonello Rubin, Barbara D. Fontana, Nathana J. Mezzomo, João Rocha, Nilda Vargas Barbosa, Daniele L. Meinerz |
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| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Endophenotypes Movement Population ved/biology.organism_classification_rank.species Biology Affect (psychology) 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine Conditioning Psychological medicine Avoidance Learning Animals Fear conditioning education Model organism Psychiatry Zebrafish education.field_of_study ved/biology Immobility Response Tonic General Medicine Fear biology.organism_classification 030227 psychiatry Disease Models Animal Endophenotype embryonic structures Anxiety Conditioning Animal Science and Zoology medicine.symptom 030217 neurology & neurosurgery |
| Zdroj: | Behavioural processes. 149 |
| ISSN: | 1872-8308 |
| Popis: | Anxiety, trauma- and stressor-related disorders are severe psychiatric conditions that affect human population worldwide. Given their genetic tractability, evolutionarily conserved neurotransmitter systems, and extensive behavioral repertoire, zebrafish have become an emergent model organism in translational neuroscience. Here, we investigate whether a single exposure to conspecific alarm substance (CAS) produces fear conditioning in zebrafish using a conditioned place aversion (CPA) paradigm, as well as the persistence of aversive responses at different time intervals. While CAS elicited freezing and erratic movements at conditioning phase, zebrafish showed a robust avoidance for the CAS-paired compartment and increased risk assessment up to 7 days postconditioning. Additionally, we observed the existence of two behavioral phenotypes (high- and low-avoider fish) that present different fear-like responses at conditioning phase and evasion of the conditioning side at postconditioning trials. Collectively, we show a prolonged conditioned place aversion in zebrafish after a single CAS conditioning session, reinforcing the use of fear conditioning protocols as valuable strategies for modeling psychiatric disorders-related phenotypes in zebrafish. |
| Databáze: | OpenAIRE |
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