Distinguishing and phenotype monitoring of traumatic brain injury and post-concussion syndrome including chronic migraine in serum of Iraq and Afghanistan war veterans

Autor: Megan R. Lerner, James R. Couch, James R. Hocker, Jay S. Hanas
Jazyk: angličtina
Rok vydání: 2019
Předmět:
0301 basic medicine
Oncology
Male
Serum Proteins
Critical Care and Emergency Medicine
Traumatic Brain Injury
Social Sciences
Disease
Pathology and Laboratory Medicine
Biochemistry
Stress Disorders
Post-Traumatic
Governments
0302 clinical medicine
Chronic Migraine
Brain Injuries
Traumatic
Medicine and Health Sciences
Depression (differential diagnoses)
Trauma Medicine
Veterans
Multidisciplinary
Afghan Campaign 2001
Headaches
Depression
Post-Concussion Syndrome
Post-Traumatic Stress Disorder
Middle Aged
Anxiety Disorders
Data Acquisition
Military Personnel
Medicine
Biomarker (medicine)
War-Related Injuries
Female
Traumatic Injury
Research Article
Adult
medicine.medical_specialty
Computer and Information Sciences
Traumatic brain injury
Science
Political Science
Migraine Disorders
Neuropsychiatric Disorders
Neuroses
Diagnosis
Differential
03 medical and health sciences
Signs and Symptoms
Diagnostic Medicine
Internal medicine
Mental Health and Psychiatry
medicine
Dementia
Humans
Iraq War
2003-2011
Migraine
Retrospective Studies
Post-concussion syndrome
business.industry
Mood Disorders
Biology and Life Sciences
Proteins
medicine.disease
United States
nervous system diseases
030104 developmental biology
nervous system
Chronic Disease
business
Neurotrauma
Armed Forces
030217 neurology & neurosurgery
Zdroj: PLoS ONE
PLoS ONE, Vol 14, Iss 4, p e0215762 (2019)
ISSN: 1932-6203
Popis: Traumatic Brain Injury (TBI) and persistent post-concussion syndrome (PCS) including chronic migraine (CM) are major health issues for civilians and the military. It is important to understand underlying biochemical mechanisms of these conditions, and be able to monitor them in an accurate and minimally invasive manner. This study describes the initial use of a novel serum analytical platform to help distinguish TBI patients, including those with post-traumatic headache (PTH), and to help identify phenotypes at play in these disorders. The hypothesis is that physiological responses to disease states like TBI and PTH and related bodily stresses are reflected in biomolecules in the blood in disease-specific manner. Leave one out (serum sample) cross validations (LOOCV) and sample randomizations were utilized to distinguished serum samples from the following TBI patient groups: TBI +PTSD + CM + severe depression (TBI "most affected" group) vs healthy controls, TBI "most affected" vs TBI, TBI vs controls, TBI + CM vs controls, and TBI + CM vs TBI. Inter-group discriminatory p values were ≤ 10-10, and sample group randomizations resulted in p non-significant values. Peptide/protein identifications of discriminatory mass peaks from the TBI "most affected" vs controls and from the TBI plus vs TBI minus CM groups yielded information of the cellular/molecular effects of these disorders (immune responses, amyloidosis/Alzheimer's disease/dementia, neuronal development). More specific biochemical disease effects appear to involve blood brain barrier, depression, migraine headache, autoimmunity, and autophagy pathways. This study demonstrated the ability for the first time of a novel, accurate, biomarker platform to monitor these conditions in serum, and help identify biochemical relationships leading to better understanding of these disorders and to potential therapeutic approaches.
Databáze: OpenAIRE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje