HPLC assay and pharmacokinetics and tissue distribution study of glycyrrhetinic acid liposomes modified with galactosylated lipid
| Autor: | Wei Wu, Lv-ping Lin, Bo-hong Guo, Yi Cheng, De-hui Lin |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Biodistribution
Liposome Chemistry Myocardium Extraction (chemistry) Galactose Pharmaceutical Science Kidney metabolism Pharmacology Kidney Lipids High-performance liquid chromatography Mice Hplc assay Liver Pharmacokinetics Delayed-Action Preparations Liposomes Animals Glycyrrhetinic Acid Tissue Distribution Tissue distribution Lung Chromatography High Pressure Liquid Spleen |
| Zdroj: | Journal of Liposome Research. 22:120-127 |
| ISSN: | 1532-2394 0898-2104 |
| DOI: | 10.3109/08982104.2011.627515 |
| Popis: | The aim of this study was to evaluate the pharmacokinetics and tissue distribution of the glycyrrhetinic acid (GA) liposome modified with galactosylated lipid (NOH-GA-LP), compared with GA conventional liposome (GA-LP) and GA solution in mice. The pharmacokinetics and biodistribution of liposomal and solution formulation of GA in mice were studied after intravenous administration. Plasma and tissues were treated using liquid-liquid extraction and determined using reversed-phase high-performance liquid chromatography. Results showed that the mean residence times of NOH-GA-LP (2.99-fold) and GA-LP (2.94-fold) were higher than that of the GA solution in plasma. NOH-GA-LP produced a drug concentration in the liver that was markedly higher than that in other tissues and was approximately 2.0- and 4.8-fold of that of GA-LP and GA solution, respectively. In conclusion, the NOH-GA-LP prepared in this study is a promising sustained-release and drug-targeting system for antitumor drugs. |
| Databáze: | OpenAIRE |
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