ICOS gene haplotypes correlate with IL10 secretion and multiple sclerosis evolution
| Autor: | Junji Yagi, Maurizio Leone, Elisa Cerutti, Mara Giordano, Elio Scarpini, Franco Perla, Sandra D'Alfonso, Umberto Dianzani, Stefania Nicola, José M. Rojo, Daniela Galimberti, Chiara Fenoglio, Fabiana Tesser, Annalisa Chiocchetti, Riccardo Mesturini, Cristoforo Comi, Francesco Monaco, Luca Castelli |
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| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
Antigens
Differentiation T-Lymphocyte Male T cell Immunology Biology Linkage Disequilibrium Statistics Nonparametric Inducible T-Cell Co-Stimulator Protein Multiple sclerosis Gene Frequency medicine Humans Immunology and Allergy Genetic Predisposition to Disease Secretion 3' Untranslated Regions Gene Haplotype Heterozygote advantage medicine.disease Interleukin-10 Costimulatory Molecule Interleukin 10 medicine.anatomical_structure Haplotypes Neurology ICOS Case-Control Studies Leukocytes Mononuclear Female Neurology (clinical) IL10 |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| Popis: | 6 páginas, 2 figuras, 3 tablas -- PAGS nros. 193-198 Human ICOS is a T cell costimulatory molecule supporting IL10 secretion. A pilot study investigating variations of the ICOS gene 3'UTR detected 8 polymorphisms forming three haplotypes (A, B, C). Haplotype-A and -C displayed the highest difference. Activated T cells from healthy AA homozygotes expressed significantly less ICOS and secreted more IL10 than AC heterozygotes, whereas AB heterozygotes displayed intermediate levels. Analysis of 441 multiple sclerosis patients and 793 controls showed that frequency of AA homozygosity was significantly lower in MS patients with relapsing–remitting onset (N = 416) than in controls (OR = 0.70). Moreover, AA patients with relapsing–remitting onset had lower relapse rate and multiple sclerosis severity score than non-AA patients This work was partially supported by Telethon grant E1170 (Rome), FISM grant 2005/R/10 (Genoa), AIRC (Milan), PRIN Project (MIUR, Rome), Fondazione Cariplo (Milan), Compagnia di San Paolo (Turin), Fondazione Cassa di Risparmio di Cuneo (Cuneo), Regione Piemonte (Turin), and Associazione “Amici di Jean” (Turin) |
| Databáze: | OpenAIRE |
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