The feasibility of Magnetic Resonance Imaging in a non-selective comprehensive clinical trial in pediatric Autism Spectrum Disorder
| Autor: | Emma Thomas, Izabella Pokorski, Indra Sadeli, Adam J. Guastella, Zahava Ambarchi, Marilena M. DeMayo, Shrujna Patel, Domenic Soligo, Ian B. Hickie, Rinku Thapa, Yun J. C. Song |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
medicine.diagnostic_test 05 social sciences Magnetic resonance imaging medicine.disease Clinical trial 03 medical and health sciences 0302 clinical medicine Neuroimaging Autism spectrum disorder Developmental and Educational Psychology medicine Physical therapy Autism 0501 psychology and cognitive sciences Mri scan Psychology 030217 neurology & neurosurgery Brain function 050104 developmental & child psychology |
| DOI: | 10.31219/osf.io/br2je |
| Popis: | There is an increasing push to identify the neurobiology associated with Autism Spectrum Disorder (ASD) including via Magnetic Resonance Imaging (MRI). Much of the previous research, however, has used behavioral or intelligence score criteria to increase feasibility of such assessments, particularly in studies investigating the effects of intervention on the brain. Such restrictions, however, exclude a significant proportion of potential participants with ASD, potentially biasing the development of subtypes and treatments. To address the need for inclusive clinical trials that include neurobiological measures, this study investigated the feasibility of MRI scanning in a comprehensive, inclusive clinical trial for children (aged 3-12 years) with ASD. No adaptive functioning or IQ score criteria were required for enrollment into the trial. Of the 71 participants who consented to the MRI component of the protocol, 24 successfully completed the scan at baseline. At post-treatment, 22 participants returned, with 21 successful scan completions. This study illustrates the possibility of MRI inclusion in comprehensive clinical trials that include a number of measures for children with ASD and highlights limitations evident when MRI is not the focus of the trial. |
| Databáze: | OpenAIRE |
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