Migraine and Two-Pore-Domain Potassium Channels
| Autor: | Verkest, Clément, Häfner, Stephanie, Ávalos Prado, Pablo, Baron, Anne, Sandoz, Guillaume, Prado, Pablo |
|---|---|
| Přispěvatelé: | Institut de Biologie Valrose (IBV), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Institut de pharmacologie moléculaire et cellulaire (IPMC), Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA), Laboratory of Excellence in Ion Channel Science and Therapeutics [Valbonne] (LabEx ICST), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), Université Côte d'Azur (UCA), Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Potassium Channels Photophobia Kozac sequence Nausea Aura Migraine Disorders [SDV]Life Sciences [q-bio] frameshift mutation-induced alternative translation initiation (fsATI) Pain Neurological disorder trigeminal sensory neurons 03 medical and health sciences 0302 clinical medicine excitability Medicine Humans Migraine ComputingMilieux_MISCELLANEOUS allodynia business.industry heterodimerization General Neuroscience Cortical Spreading Depression KCNK medicine.disease Migraine with aura 3. Good health 030104 developmental biology Allodynia K 2P channels Anesthesia Cortical spreading depression Neurology (clinical) medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | Neuroscientist Neuroscientist, SAGE Publications, 2020, pp.107385842094094. ⟨10.1177/1073858420940949⟩ Neuroscientist, SAGE Publications, 2021, 27 (3), pp.268-284. ⟨10.1177/1073858420940949⟩ |
| ISSN: | 1073-8584 |
| DOI: | 10.1177/1073858420940949⟩ |
| Popis: | Migraine is a common, disabling neurological disorder with a genetic, environmental, and hormonal component with an annual prevalence estimated at ~15%. It is characterized by attacks of severe, usually unilateral and throbbing headache, and can be accompanied by nausea, vomiting, and photophobia. Migraine is clinically divided into two main subtypes: migraine with aura, when it is preceded by transient neurological disturbances due to cortical spreading depression (CSD), and migraine without aura. Activation and sensitization of trigeminal sensory neurons, leading to the release of pro-inflammatory peptides, is likely a key component in headache pain initiation and transmission in migraine. In the present review, we will focus on the function of two-pore-domain potassium (K2P) channels, which control trigeminal sensory neuron excitability and their potential interest for developing new drugs to treat migraine. |
| Databáze: | OpenAIRE |
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