Ameliorative Effect of Curcumin on Olanzapine-induced Obesity in Sprague-Dawley Rats
| Autor: | Khor Ming Zhen, Subramani Parasuraman, Urmila Banik, Parayil Varghese Christapher |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Olanzapine obesity olanzapine Pharmacology Body weight 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Drug Discovery Sprague dawley rats Medicine Betahistine curcumin Normal control business.industry Liver and kidney medicine.disease Obesity 030104 developmental biology chemistry Curcumin Original Article business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Pharmacognosy Research |
| ISSN: | 0976-4836 |
| Popis: | Objective: To evaluate the effect of curcumin on olanzapine-induced obesity in rats. Materials and Methods: Sprague-Dawley (SD) rats were used for experiments. The animals were divided into six groups, namely, normal control, olanzapine control, betahistine (10 mg/kg), and curcumin 50, 100, and 200 mg/kg treated groups. Except the normal control group, all other animals were administered with olanzapine 4 mg/kg intraperitoneally to induce obesity. The drugs were administered once daily, per oral for 28 days. During the experiment, body weight changes and behavior alterations were monitored at regular intervals. At the end of the experiment, blood sample was collected from all the experimental animals for biochemical analysis. Part of the liver and kidney tissues was harvested from the sacrificed animals and preserved in neutral formalin for histopathological studies. Results: Curcumin showed a significant reduction in olanzapine-induced body weight gain on the rats and improved the locomotor effects. The effect of curcumin on olanzapine-induced body weight gain is not comparable with that of betahistine. Conclusion: This study has shown metabolic alteration effect of curcumin on olanzapine, an antipsychotic drug, treated SD rats. SUMMARY Olanzapine is an atypical antipsychotic drug used for the treatment of schizophrenia and bipolar disorder. Obesity is an adverse effect of olanzapine, and the present study was made an attempt to study the effect of curcumin on olanzapine-induced obesity in rats. In this present study, curcumin significantly reduced olanzapine-induced body weight gain in rats. Abbreviations Used: 5HT: 5-hydroxytryptamine, ALP: Alkaline phosphatase, ALT: Alanine transaminase, ANOVA: Analysis of variance, AST: Aspartate transaminase, CMC: Carboxymethyl cellulose, D: Dopamine, H and E: Hematoxylin and Eosin stain, H: Histamine, HDL-C: Highdensity lipoprotein cholesterol, IP: Intraperitoneal, MAO: Monoamine oxidase, NaOH: Sodium hydroxide, SD rats: Sprague Dawley rats, TCs: Total cholesterols, TG: Triglyceride. |
| Databáze: | OpenAIRE |
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