Fatty acid synthase and Ki‐67 immunoexpression can be useful for the identification of malignant component in carcinoma ex‐pleomorphic adenoma

Autor:	Rogério Gondak, Pablo Agustin Vargas, Albina Altemani, Fernanda Viviane Mariano, Leandro Aurelio Liporoni Martins, Jorge Esquiche León, Oslei Paes de Almeida, Katya Pulido Díaz
Rok vydání:	2019
Předmět:	Adult Male Cancer Research Adolescent Adenoma Proliferation index Adenoma Pleomorphic Gene Expression Pathology and Forensic Medicine Malignant transformation Neoplasms Multiple Primary Young Adult 03 medical and health sciences 0302 clinical medicine Biomarkers Tumor medicine Humans Aged Aged 80 and over biology Chemistry Carcinoma Myoepithelial cell 030206 dentistry Middle Aged Salivary Gland Neoplasms medicine.disease Immunohistochemistry Fatty Acid Synthase Type I Fatty acid synthase Cell Transformation Neoplastic Ki-67 Antigen Carcinoma ex pleomorphic adenoma Otorhinolaryngology 030220 oncology & carcinogenesis Ki-67 Cancer research biology.protein Periodontics Female Oral Surgery
Zdroj:	Journal of Oral Pathology & Medicine. 48:232-238
ISSN:	1600-0714 0904-2512
DOI:	10.1111/jop.12820
Popis:	BACKGROUND Fatty acid synthase (FASN) is the key molecule for catalyzing fatty acid synthesis and have been associated with several malignant tumors. METHODS We analyzed the expression of FASN and Ki-67, by immunohistochemistry on 29 carcinomas ex-pleomorphic adenoma (CXPAs) and 25 pleomorphic adenomas (PAs). RESULTS Ki-67 proliferation index and FASN expression were significantly higher in patients with CXPA than patients with PA (P
Databáze:	OpenAIRE
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