Evaluating the effectiveness of rosuvastatin in preventing the progression of diastolic dysfunction in aortic stenosis: A substudy of the aortic stenosis progression observation measuring effects of rosuvastatin (ASTRONOMER) study
| Autor: | Davinder S. Jassal, Erin Karlstedt, Jean G. Dumesnil, Kapil M Bhagirath, James W. Tam, Koon K. Teo, Matthew R. Zeglinski, Kwan L. Chan |
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| Jazyk: | angličtina |
| Předmět: |
Adult
Male medicine.medical_specialty lcsh:Diseases of the circulatory (Cardiovascular) system Diastole Doppler echocardiography Left ventricular hypertrophy Doppler imaging Severity of Illness Index Internal medicine medicine Humans Multicenter Studies as Topic Radiology Nuclear Medicine and imaging Rosuvastatin Rosuvastatin Calcium Aged Heart Failure Diastolic Sulfonamides medicine.diagnostic_test business.industry Research General Medicine Aortic Valve Stenosis Middle Aged medicine.disease Echocardiography Doppler Fluorobenzenes Stenosis Pyrimidines lcsh:RC666-701 Radiology Nuclear Medicine and imaging Aortic valve stenosis Cardiology Disease Progression Female Hydroxymethylglutaryl-CoA Reductase Inhibitors business Cardiology and Cardiovascular Medicine medicine.drug Follow-Up Studies |
| Zdroj: | Cardiovascular Ultrasound Cardiovascular Ultrasound, Vol 9, Iss 1, p 5 (2011) |
| ISSN: | 1476-7120 |
| DOI: | 10.1186/1476-7120-9-5 |
| Popis: | Background Tissue Doppler imaging (TDI) is a noninvasive echocardiographic method for the diagnosis of diastolic dysfunction in patients with varying degrees of aortic stenosis (AS). Little is known however, on the utility of TDI in the serial assessment of diastolic abnormalities in AS. Objective The aim of the current proposal was to examine whether treatment with rosuvastatin was successful in improving diastolic abnormalities in patients enrolled in the Aortic Stenosis Progression Observation Measuring Effects of Rosuvastatin (ASTRONOMER) study. Methods Conventional Doppler indices including peak early (E) and late (A) transmitral velocities, and E/A ratio were measured from spectral Doppler. Tissue Doppler measurements including early (E') and late (A') velocities of the lateral annulus were determined, and E/E' was calculated. Results The study population included 168 patients (56 ± 13 years), whose AS severity was categorized based on peak velocity at baseline (Group I: 2.5-3.0 m/s; Group II: 3.1-3.5 m/s; Group III: 3.6-4.0 m/s). Baseline and follow-up hemodynamics, LV dimensions and diastolic functional parameters were evaluated in all three groups. There was increased diastolic dysfunction from baseline to follow-up in each of the placebo and rosuvastatin groups. In patients with increasing severity of AS in Groups I and II, the lateral E' was lower and the E/E' (as an estimate of increased left ventricular end-diastolic pressure) was higher at baseline (p < 0.05). However, treatment with rosuvastatin did not affect the progression of diastolic dysfunction from baseline to 3.5 year follow-up between patients in any of the three predefined groups. Conclusion In patients with mild to moderate asymptomatic AS, rosuvastatin did not attenuate the progression of diastolic dysfunction. |
| Databáze: | OpenAIRE |
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