Decreased regional cerebral blood flow in medial prefrontal cortex during trauma-unrelated stressful imagery in Vietnam veterans with post-traumatic stress disorder
| Autor: | Natasha B. Lasko, Linda J. Metzger, Michael L. Macklin, Darin D. Dougherty, Scott L. Rauch, Roger K. Pitman, Lisa M. Shin, Margaret A. Carson, Andrea L. Gold, Alan J. Fischman, Nathaniel M. Alpert, Scott P. Orr |
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| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty Prefrontal Cortex behavioral disciplines and activities Amygdala Vietnam Conflict Stress Disorders Post-Traumatic Neuroimaging mental disorders medicine Humans Psychiatry Prefrontal cortex Applied Psychology Anterior cingulate cortex Aged Veterans Recall Traumatic stress Middle Aged United States Psychiatry and Mental health medicine.anatomical_structure Cerebral blood flow Cerebrovascular Circulation Positron-Emission Tomography Anxiety Female medicine.symptom Psychology Stress Psychological Clinical psychology |
| Zdroj: | Psychological Medicine. 41:2563-2572 |
| ISSN: | 1469-8978 0033-2917 |
| Popis: | BackgroundNeuroimaging research has demonstrated medial prefrontal cortex (mPFC) hyporesponsivity and amygdala hyperresponsivity to trauma-related or emotional stimuli in post-traumatic stress disorder (PTSD). Relatively few studies have examined brain responses to the recollection of stressful, but trauma-unrelated, personal events in PTSD. In the current study, we sought to determine whether regional cerebral blood flow (rCBF) abnormalities in mPFC and amygdala in PTSD could be observed during the recollection of trauma-unrelated stressful personal events.MethodParticipants were 35 right-handed male combat veterans (MCVs) and female nurse veterans (FNVs) who served in Vietnam: 17 (seven male, 10 female) with current military-related PTSD and 18 (nine male, nine female) with no current or lifetime PTSD. We used positron emission tomography (PET) and script-driven imagery to study rCBF during the recollection of trauma-unrelated stressful versus neutral and traumatic events.ResultsVoxelwise tests revealed significant between-group differences for the trauma-unrelated stressful versus neutral comparison in mPFC, specifically in the anterior cingulate cortex (ACC). Functional region of interest (ROI) analyses demonstrated that this interaction in mPFC represented greater rCBF decreases in the PTSD group during trauma-unrelated stressful imagery relative to neutral imagery compared to the non-PTSD group. No differential amygdala activation was observed between groups or in either group separately.ConclusionsVeterans with PTSD, compared to those without PTSD, exhibited decreased rCBF in mPFC during mental imagery of trauma-unrelated stressful personal experiences. Functional neuroanatomical models of PTSD must account for diminished mPFC responses that extend to emotional stimuli, including stressful personal experiences that are not directly related to PTSD. |
| Databáze: | OpenAIRE |
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