Toward a Long-Term Artificial Lung
| Autor: | Thomas Schmitz-Rode, Hans Peter Wendel, Rolf Rossaint, Jutta Arens, Oliver Grottke, Axel Haverich, Lars S. Maier, Ulrich Steinseifer |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
lung support
Computer science lung assist structural integration Biomedical Engineering Biophysics Bioengineering Economic shortage Review Article 030204 cardiovascular system & hematology implantable artificial lung In vivo tests in vitro verification Artificial lung Biomaterials miniaturization 03 medical and health sciences 0302 clinical medicine anticoagulation regimes biocompatibility in silico analysis Animals Humans Lung artificial lung General Medicine Limiting hemocompatibility Clot formation Transplantation 030228 respiratory system Risk analysis (engineering) in vivo validation Artificial Organs ECMO Destination therapy |
| Zdroj: | Asaio Journal |
| ISSN: | 1058-2916 |
| Popis: | Only a very small portion of end-stage organ failures can be treated by transplantation because of the shortage of donor organs. Although artificial long-term organ support such as ventricular assist devices provide therapeutic options serving as a bridge-to-transplantation or destination therapy for end-stage heart failure, suitable long-term artificial lung systems are still at an early stage of development. Although a short-term use of an extracorporeal lung support is feasible today, the currently available technical solutions do not permit the long-term use of lung replacement systems in terms of an implantable artificial lung. This is currently limited by a variety of factors: biocompatibility problems lead to clot formation within the system, especially in areas with unphysiological flow conditions. In addition, proteins, cells, and fibrin are deposited on the membranes, decreasing gas exchange performance and thus, limiting long-term use. Coordinated basic and translational scientific research to solve these problems is therefore necessary to enable the long-term use and implantation of an artificial lung. Strategies for improving the biocompatibility of foreign surfaces, for new anticoagulation regimes, for optimization of gas and blood flow, and for miniaturization of these systems must be found. These strategies must be validated by in vitro and in vivo tests, which remain to be developed. In addition, the influence of long-term support on the pathophysiology must be considered. These challenges require well-connected interdisciplinary teams from the natural and material sciences, engineering, and medicine, which take the necessary steps toward the development of an artificial implantable lung. |
| Databáze: | OpenAIRE |
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