Transfer of insulin-dependent diabetes between HLA-identical siblings by bone marrow transplantation

Autor:	F. A. Gries, M. Homberg, Hubert Kolb, Hans Grosse-Wilde, J. Bertrams, U.W. Schaefer, Lampeter Ef, K. Quabeck, Peter Wernet
Rok vydání:	1993
Předmět:	Adult Male medicine.medical_treatment Human leukocyte antigen Islets of Langerhans Immune system HLA Antigens Diabetes mellitus Medicine Humans Aplastic anemia Autoantibodies Bone Marrow Transplantation geography geography.geographical_feature_category business.industry Insulin General Medicine Islet medicine.disease Transplantation medicine.anatomical_structure Diabetes Mellitus Type 1 Myelodysplastic Syndromes Immunology Female Bone marrow business
Zdroj:	Lancet (London, England). 341(8855)
ISSN:	0140-6736
Popis:	Insulin-dependent diabetes was observed in a woman, aged 29, 4 years after transplantation of bone marrow from her HLA-identical brother with insulin-dependent diabetes. Both had classic symptoms and insulin dependency from onset. At diagnosis of diabetes the recipient was positive for high-titre islet cell antibodies (ICA) whereas she had been ICA negative before transplantation. Chromosomal analyses verified that all circulating leucocytes were of male donor type. These findings suggest transfer of insulin-dependent diabetes by bone marrow cells and confirm the immune nature of the disease.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12fc1f814ef9702306e83b53420fdf7b https://pubmed.ncbi.nlm.nih.gov/8101268 Zobrazit plný text záznamu Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.