Effect of Bcl-2 expression on hepatic preneoplasia in mice
| Autor: | Myriam Bennoun, Pascale Briand, Raphaëlle Gillet, Catherine Cavard, Alexandre Mignon, Gisèle Grimber, Virginie Joulin |
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| Rok vydání: | 2002 |
| Předmět: |
Genetically modified mouse
Cancer Research Pathology medicine.medical_specialty Programmed cell death Transgene Antigens Polyomavirus Transforming Apoptosis Mice Transgenic Biology medicine.disease_cause Transgenic Model Mice medicine Animals Liver Neoplasms medicine.disease Genes bcl-2 Gene Expression Regulation Neoplastic medicine.anatomical_structure Cell Transformation Neoplastic Oncology Hepatocellular carcinoma Hepatocyte Cancer research Carcinogenesis Precancerous Conditions |
| Zdroj: | Cancer letters. 177(2) |
| ISSN: | 0304-3835 |
| Popis: | In a transgenic model of hepatocellular carcinoma induced by the expression of SV40 early sequences (TAg mice), deregulation of hepatocyte proliferation induces an apoptotic process whose decrease coincides with the appearance of neoplastic foci. Mating these mice with transgenic mice overexpressing Bcl-2 led to a dramatic reduction in the number of apoptotic hepatocytes during preneoplasia, resulting in an enlargement of the liver. This decrease in apoptosis was followed, 2 weeks later, by a reduction in hepatocellular proliferation. Sequential reduction in apoptosis and proliferation rate suggests that the anti-apoptotic and the anti-mitotic activities of Bcl-2 might be operative in distinct stages of preneoplasia. |
| Databáze: | OpenAIRE |
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