A Roadmap to Heart Regeneration Through Conserved Mechanisms in Zebrafish And Mammals
| Autor: | Alexander W Goff, Ravi Karra, Paige DeBenedittis, Kyla D Brezitski |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Cell type 030204 cardiovascular system & hematology Article 03 medical and health sciences Mice 0302 clinical medicine medicine Animals Humans Regeneration Myocytes Cardiac 030212 general & internal medicine Cardiomyocyte proliferation Zebrafish Cell Proliferation Mammals biology business.industry Regeneration (biology) Neonatal mouse Translation (biology) Heart Cell cycle medicine.disease biology.organism_classification Cell biology Heart failure Cardiology and Cardiovascular Medicine business |
| Zdroj: | Curr Cardiol Rep |
| Popis: | PURPOSE OF REVIEW: The replenishment of lost or damaged myocardium has the potential to reverse heart failure, making heart regeneration a goal for cardiovascular medicine. Unlike adult mammals, injury to the zebrafish or neonatal mouse heart induces a robust regenerative program with minimal scarring. Recent insights into the cellular and molecular mechanisms of heart regeneration suggest that the machinery for regeneration is conserved from zebrafish to mammals. Here, we will review conserved mechanisms of heart regeneration and their translational implications. RECENT FINDINGS: Based on studies in zebrafish and neonatal mice, cardiomyocyte proliferation has emerged as a primary strategy for effecting regeneration in the adult mammalian heart. Recent work has revealed pathways for stimulating cardiomyocyte cell-cycle reentry; potential developmental barriers for cardiomyocyte proliferation; and the critical role of additional cell types to support heart regeneration. SUMMARY: Studies in zebrafish and neonatal mice have established a template for heart regeneration. Continued comparative work has the potential to inform the translation of regenerative biology into therapeutics. |
| Databáze: | OpenAIRE |
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