Hematological malignancies in connective tissue diseases
| Autor: | Hussein A. Noureldine, Imad Uthman, Mohammad Hassan Hodroj, Wared Nour-Eldine, Ali T. Taher, Mohammad Hassan A. Noureldine |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_treatment
Connective tissue Inflammation medicine.disease_cause Autoimmune Diseases Pathogenesis 03 medical and health sciences 0302 clinical medicine Rheumatology Risk Factors Rheumatic Diseases medicine Humans Lupus Erythematosus Systemic Connective Tissue Diseases 030203 arthritis & rheumatology Scleroderma Systemic business.industry Immunosuppression Immune dysregulation medicine.disease Immunosurveillance Sjogren's Syndrome medicine.anatomical_structure Hematologic Neoplasms 030220 oncology & carcinogenesis Rheumatoid arthritis Immunology medicine.symptom business Cancer risk |
| Zdroj: | Lupus. 29:225-235 |
| ISSN: | 1477-0962 0961-2033 |
| DOI: | 10.1177/0961203319899986 |
| Popis: | Chronic inflammation has profound tumor-promoting effects. Inflammatory cells are the key players in immunosurveillance against tumors, and immunosuppression is known to increase the risk of tumors. Autoimmune diseases, which manifest as loss of self-tolerance and chronic immune dysregulation, provide a perfect environment for tumor development. Aside from managing the direct inflammatory consequences of autoimmune pathogenesis, cancer risk profiles should be considered as a part of a patient's treatment. In this review, we describe the various associations of malignancies with autoimmune diseases, specifically systemic lupus erythematosus, rheumatoid arthritis, systemic sclerosis, and Sjögren's syndrome, as well as discuss the mechanisms contributing to the pathogenesis of both disorders. |
| Databáze: | OpenAIRE |
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