(6S)-6-fluoroshikimic acid, an antibacterial agent acting on the aromatic biosynthetic pathway
| Autor: | P E Pinder, Wright W. Nichols, W J Watkins, K J Barrett-Bee, J. L. Thain, G M Davies, R G Wilson, M Lehan, David A. Jude |
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| Rok vydání: | 1994 |
| Předmět: |
Male
Swine Shikimic Acid Microbial Sensitivity Tests medicine.disease_cause Shikimate kinase Microbiology Mice chemistry.chemical_compound Biosynthesis Escherichia coli medicine Animals Pharmacology (medical) Escherichia coli Infections Antibacterial agent Pharmacology biology biology.organism_classification Enterobacteriaceae In vitro Anti-Bacterial Agents Infectious Diseases Mechanism of action chemistry Biochemistry medicine.symptom Bacteria Research Article |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 38:403-406 |
| ISSN: | 1098-6596 0066-4804 |
| DOI: | 10.1128/aac.38.2.403 |
| Popis: | (6S)-6-Fluoroshikimic acid inhibited the growth of Escherichia coli B on minimal medium (MIC, 0.25 micrograms ml-1), and it protected mice challenged intraperitoneally with the same organism (50% protective dose, 0.06 mg kg of body weight-1). We propose that inhibitors of bacterial aromatic biosynthesis have the potential for use in human medicine. |
| Databáze: | OpenAIRE |
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