Increased responsiveness of sensory neurons in the saphenous nerve of the streptozotocin-diabetic rat
| Autor: | S. C. Ahlgren, J. D. Levine, D. M. White |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Male
medicine.medical_specialty endocrine system diseases Physiology Neural Conduction Action Potentials Sensory system Stimulus (physiology) Nerve Fibers Myelinated Diabetes Mellitus Experimental Rats Sprague-Dawley Nerve Fibers Physical Stimulation Internal medicine medicine Animals Neurons Afferent Chemistry General Neuroscience nutritional and metabolic diseases Streptozotocin Pathophysiology Rats Electrophysiology Saphenous nerve Endocrinology Nociception Sensory Thresholds Hyperalgesia medicine.symptom Mechanoreceptors Neuroscience medicine.drug |
| Zdroj: | Journal of Neurophysiology. 68:2077-2085 |
| ISSN: | 1522-1598 0022-3077 |
| DOI: | 10.1152/jn.1992.68.6.2077 |
| Popis: | 1. This study examined sensory neurons in the saphenous nerve of rats treated with streptozotocin to induce diabetes (STZ-D). Several physiological properties of sensory neurons were not significantly different in STZ-D compared with control (CON) rats, including percentage and rate of spontaneous activity seen in the whole nerve and mechanical and thermal thresholds of individual C-fibers. 2. The response of STZ-D and CON C-fibers to a sustained (1 min) mechanical stimulus of threshold force was similar. However, during the 5 min immediately after removal of this stimulus, there was a much greater afterdischarge in STZ-D rats (STZ-D: n = 35; 14.6 +/- 5.1 action potentials/5 min, mean +/- SE; CON: n = 34; 3.9 +/- 0.7 action potentials/5 min). The number of action potentials during a sustained (1 min) suprathreshold mechanical (445 g) stimulus was also significantly greater in the C-fibers from STZ-D rats (STZ-D: n = 44; 149.7 +/- 18.4 action potentials; CON: n = 45; 84.7 +/- 12.2 action potentials). The afterdischarge during the 5 min immediately after removal of the sustained suprathreshold stimulus was also greater in C-fibers from STZ-D rats (STZ-D: 38.7 +/- 13.1 action potentials/5 min; CON: 9.3 +/- 2.3 action potentials/5 min). 3. There was a significant difference between C-fibers from STZ-D and CON rats with respect to the distribution among certain sensory classes.(ABSTRACT TRUNCATED AT 250 WORDS) |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|