Immunosuppressive effects of extracts of helminthic parasites in C57BL mice
| Autor: | Patricia Price, KJ Turner |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Spleen
Biology Lymphocyte Activation Immunoglobulin G Immune tolerance Mice Peritoneum Immune Tolerance medicine Animals Macrophage Nippostrongylus Nippostrongylus brasiliensis Nematode Infections Nematospiroides dubius biology.organism_classification Mice Inbred C57BL Ovalbumin Infectious Diseases medicine.anatomical_structure Immunoglobulin M Antigens Helminth Immunology biology.protein Immunization Parasitology Heligmosomatoidea |
| Zdroj: | International Journal for Parasitology. 16:607-615 |
| ISSN: | 0020-7519 |
| DOI: | 10.1016/0020-7519(86)90028-7 |
| Popis: | Price P. and Turner K.J. 1986. Immunosuppressive effects of extracts of helminthic parasites in C57BL mice. International Journal for Parasitology 16 : 607–615. Crude saline extracts of adult Nematospiroides dubius or Nippostrongylus brasiliensis worms administered with an i.p. immunization of ovalbumin (OA) in Al(OH) 3 depressed primary and secondary IgG responses, delayed-type hypersensitivity and in vitro splenic lymphoproliferative responses to the OA. The suppressive agent was trypsin-sensitive and was also present in larval extracts of the above parasites at levels proportional to their protein contents. Residual gut contents from infected mice caused no suppression. The extracts had little effect on the uptake of 125 I-PVP from the peritoneum or on peritoneal macrophage activation as assessed by cell numbers, lymphocystostatic potential and acid phosphatase activity. When present in cultures of normal spleen cells, the extracts impaired mitogen-induced lymphoproliferation if added with or before the mitogen. Possible roles for suppressor T cells, suppressive peritoneal or splenic macrophages and direct inhibition of clonal expansion in the suppression of the responses to OA are discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|