Metallic Nanoparticles: A Useful Prompt Gamma Emitter for Range Monitoring in Proton Therapy?
| Autor: | Julien L. Colaux, Félicien Hespeels, Sébastien Penninckx, Anne-Catherine Heuskin, Stéphane Lucas, Julien Smeets |
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| Rok vydání: | 2021 |
| Předmět: |
Dose delivery
Range (particle radiation) radiosensitizer Materials science R895-920 Planning target volume General Medicine prompt gamma nanoparticles proton therapy radioenhancer Medical physicist Medical physics. Medical radiology. Nuclear medicine Metal nanoparticles Proton therapy Beam (structure) Biomedical engineering Common emitter |
| Zdroj: | Penninckx, S, Hespeels, F, Smeets, J, Colaux, J, Lucas, S & Heuskin, A-C 2021, ' Metallic Nanoparticles : A Useful Prompt Gamma Emitter for Range Monitoring in Proton Therapy? ', Radiation, vol. 1, no. 4, pp. 305-316 . https://doi.org/10.3390/radiation1040025 Radiation and Its Application in Oncology and Radiation Protection Radiation; Volume 1; Issue 4; Pages: 305-316 Radiation, Vol 1, Iss 25, Pp 305-316 (2021) |
| ISSN: | 2673-592X |
| DOI: | 10.3390/radiation1040025 |
| Popis: | In clinical practice, dose delivery in proton therapy treatment is affected by uncertainties related to the range of the beam in the patient, which requires medical physicists to introduce safety margins on the penetration depth of the beam. Although this ensures an irradiation of the entire clinical target volume with the prescribed dose, these safety margins also lead to the exposure of nearby healthy tissues and a subsequent risk of side effects. Therefore, non-invasive techniques that allow for margin reduction through online monitoring of prompt gammas emitted along the proton tracks in the patient are currently under development. This study provides the proof-of-concept of metal-based nanoparticles, injected into the tumor, as a prompt gamma enhancer, helping in the beam range verification. It identifies the limitations of this application, suggesting a low feasibility in a realistic clinical scenario but opens some avenues for improvement. |
| Databáze: | OpenAIRE |
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