Expression of vascular endothelial growth factor in retinoblastoma
| Autor: | Imelda de Pifano, Miguel N. Burnier, D. Abourbih, Carolina Areán, Maria Eugenia Orellana, Carmen Abreu |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Vascular Endothelial Growth Factor A Pathology medicine.medical_specialty Retinal Neoplasm Mitotic index Retinal Neoplasms Apoptosis Immunoenzyme Techniques chemistry.chemical_compound medicine Mitotic Index Humans Neoplasm Invasiveness Neoplasm Staging Retrospective Studies Neovascularization Pathologic Retinoblastoma business.industry Cancer Cell Differentiation medicine.disease Vascular endothelial growth factor Ophthalmology Vascular endothelial growth factor A chemistry Tumor progression Child Preschool Disease Progression Immunohistochemistry Female business |
| Zdroj: | Archives of ophthalmology (Chicago, Ill. : 1960). 128(2) |
| ISSN: | 1538-3601 |
| Popis: | Objectives To investigate the immunohistochemical expression of vascular endothelial growth factor (VEGF) and to determine its possible association with tumor differentiation status, optic nerve and/or choroidal invasion, anterior chamber invasion, vitreous seeding, and basophilic staining of the vascular walls. Methods A retrospective study was performed to identify the expression of VEGF in 47 of 129 consecutive patients with retinoblastoma treated at the Ocular Pathology Laboratory of the Anatomy and Pathology Institute of the Central University of Venezuela in Caracas from January 1, 2000, through December 31, 2007. Results A positive correlation between VEGF staining intensity and time of progression and mitotic and apoptotic indexes was observed. However, no correlation was found between VEGF expression and other prognostic factors in this malignant neoplasm, including tumor stage as assessed by the Grabowski and Abramson classification. Conclusions Although the isolated characterization of VEGF in retinoblastoma is not grounds for this protein to be considered a prognostic factor, its association with mitotic and apoptotic indexes suggests it may play a role in the progression of this disease. Thus, therapeutic targeting of VEGF in retinoblastoma may be an effective strategy to reduce tumor progression. |
| Databáze: | OpenAIRE |
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