Immunohistochemical Expression of Osteopontin in Gastric Cancer
| Autor: | Atsushi Yasuda, Motohiro Imano, Masayuki Shinkai, Hitoshi Shiozaki, Tatsuki Itoh, Eizaburo Ishimaru, Takao Satou, Harumasa Ohyanagi, Kiyokata Okuno, Hiroyuki Ito, Ying-Feng Peng, Fumiharu Akai, Haruhiko Imamoto, Kenichi Sakai, Takushi Yasuda |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Apoptosis Sensitivity and Specificity Sampling Studies stomatognathic system Stomach Neoplasms Biopsy Biomarkers Tumor medicine Humans Neoplasm Invasiveness Osteopontin Aged Cell Proliferation Neoplasm Staging Probability Retrospective Studies Aged 80 and over medicine.diagnostic_test biology Cell growth business.industry Biopsy Needle Gastroenterology Cancer Middle Aged medicine.disease Immunohistochemistry Gastric Mucosa Cancer cell biology.protein Female Surgery Neoplasm staging business |
| Zdroj: | Journal of Gastrointestinal Surgery. 13:1577-1582 |
| ISSN: | 1873-4626 1091-255X |
| DOI: | 10.1007/s11605-009-0955-y |
| Popis: | Osteopontin (OPN) is significantly overexpressed in a variety of malignancies. However, little is known concerning the significance of OPN expression in human cancers. Thus, the aim of this study was to determine the relationship between the degree of OPN expression, the proliferative activity of cancer cells, and the clinicopathological findings for surgically resected gastric cancer.We evaluated the immunohistochemical expression of OPN in 85 specimens of cancer. Additionally, we investigated a cancer cell proliferative index using an anti-MIB-1 antibody and terminal deoxynucleotidyl transferase-mediated dUTP biotin nick end labeling staining. Levels of OPN expression in gastric cancers were classified into three groups. To compare the relationship between OPN expression and clinicopathological findings, the features of cancer lesions were classified using the TNM Classification of Malignant Tumors, 6th Edition.Immunohistochemical examination of OPN expression in gastric cancer revealed diffuse granular staining in the cytoplasm. High OPN expression was observed in 37 of 85 carcinomas. Strong OPN expression was significantly associated with a low apoptotic index, a high proliferative index, depth of invasion, lymphatic invasion, and venous invasion. Pathologically, intestinal type carcinoma showed strong expression of OPN.These data suggested that OPN may play an important role in the invasiveness and the progressive nature of gastric cancer. |
| Databáze: | OpenAIRE |
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