Antileishmanial Potential of Tropical Rainforest Plant Extracts
| Autor: | William N. Setzer, Abel Piñón, Lianet Monzote |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Zimbabwe
Costa Rica Endiandra palmerstonii Far North Queensland Bahamas complex mixtures Article chemistry.chemical_compound Botany Acetone leishmaniasis IC50 General Environmental Science Chloroform Sassafras albidum Ethanol biology Traditional medicine Leishmania amazonensis Matabeleland Australia General Engineering Monteverde 15. Life on land biology.organism_classification Abaco island Phytochemical chemistry visual_art visual_art.visual_art_medium General Earth and Planetary Sciences Bark |
| Zdroj: | Medicines Volume 1 Issue 1 Pages 32-55 |
| ISSN: | 2305-6320 |
| DOI: | 10.3390/medicines1010032 |
| Popis: | A total of 115 different plant extracts from our collection, representing 96 plant species, have been evaluated for in vitro antileishmanial activity against L. amazonensis promastigotes. In addition, the extracts were screened for cytotoxic activity against BALB/c mouse macrophages in order to assess a selectivity index. Crude extracts that showed a selectivity index (CC50 for macrophage / IC50 for promastigotes) ³ 5 or with IC50 < 12.5 μg/mL against promastigotes, a total of 28 extracts, were further screened for anti-amastigote activity. A total of 25 extracts showed promising activity against L. amazonensis promastigotes with low cytotoxic activity. Ten of these extracts showed selectivity indices, (CC50 for macrophages / IC50 for amastigotes) greater than 10 and are considered “hits”, worthy candidates for further phytochemical exploration: Conostegia xalapensis methanol bark extract, Endiandra palmerstonii bark extract, Eugenia monteverdensis acetone bark extract, Eugenia sp. “fine leaf” acetone bark extract, Exothea paniculata chloroform bark extract, Mallotus paniculatus ethanol bark extract, Matelea pseudobarbata ethanol extract, Quercus insignis ethanol bark extract, Sassafras albidum dichloromethane bark extract, and Stemmadenia donnell-smithii acetone bark extract. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|