Motor cortex hypoexcitability and hypoactivation in COPD patients with peripheral muscle weakness
| Autor: | Alain Varray, Nelly Héraud, Dominique Bourgouin, Nicolas Oliver, François Alexandre, Emilie Tremey |
|---|---|
| Přispěvatelé: | Euromov (EuroMov), Université de Montpellier (UM), Laboratoire de Chimie et Biologie des Métaux (LCBM - UMR 5249), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Groupe 5 Santé [Lodève, France] (Les Cliniques du Souffle), Les Cliniques du Souffle [Lodève, France], Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA) |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
COPD
Weakness medicine.medical_specialty business.industry [SCCO.NEUR]Cognitive science/Neuroscience Muscle weakness Stimulation medicine.disease [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract respiratory tract diseases Peripheral medicine.anatomical_structure Physical medicine and rehabilitation Internal medicine medicine Cardiology [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO] Silent period medicine.symptom business ComputingMilieux_MISCELLANEOUS Motor cortex Peripheral muscle |
| Zdroj: | ERS International Congress 2016 abstracts ERS International Congress 2016 abstracts, Sep 2016, Londres, United Kingdom. pp.OA4809, ⟨10.1183/13993003.congress-2016.OA4809⟩ |
| DOI: | 10.1183/13993003.congress-2016.OA4809⟩ |
| Popis: | Peripheral muscle weakness can be caused by both peripheral muscle and neural alterations. Although peripheral alterations cannot totally explain peripheral muscle weakness in COPD, the existence of an activation deficit remains controversial. The heterogeneity of muscle weakness (32 to 57%) is generally not controlled in studies and could explain this discrepancy. This study aimed to compare voluntary activation levels between control subjects, COPD patients with and without muscle weakness. Twenty-two patients with quadriceps weakness (COPD MW ), 18 patients with preserved quadriceps strength (COPD NoMW ) and 20 controls were recruited. Voluntary activation was measured through peripheral nerve (VA peripheral ) and transcranial magnetic (VA cortical ) stimulation. Corticospinal and spinal excitability (MEP/Mmax and Hmax/Mmax) and corticospinal inhibition (silent period duration) were assessed during maximal voluntary quadriceps contractions. COPD MW exhibited lower VA cortical and lower MEP/Mmax compared to COPD NoMW and controls (p cortical and MEP/Mmax. COPD patients with muscle weakness have reduced voluntary activation without altered spinal excitability. Corticospinal inhibition is higher in COPD regardless of muscle weakness. Therefore, reduced cortical excitability and a voluntary activation deficit from the motor cortex are the most likely cortical mechanisms implicated in COPD muscle weakness. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|