Effects of French maritime pine bark/bilberry fruit extracts on intraocular pressure for primary open-angle glaucoma
| Autor: | Kaoru Manabe, Mihoko Mochiji, Etsuyo Miyamoto, Yasutaka Takagi, Masaki Tanito, Sachiko Kaidzu, Aika Tsutsui, Yotaro Matsuoka |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Intraocular pressure medicine.medical_specialty sulfhydryl (SH) test Bilberry genetic structures Open angle glaucoma Fruit extracts Clinical Biochemistry Medicine (miscellaneous) Glaucoma biological antioxidant potential (BAP) test anthocyanin 03 medical and health sciences 0302 clinical medicine Ophthalmology Medicine Morning 030109 nutrition & dietetics Nutrition and Dietetics business.industry Pycnogenol® Mirtoselect® ANTIGLAUCOMA MEDICATIONS medicine.disease eye diseases visual_art procyanidin visual_art.visual_art_medium Original Article 030211 gastroenterology & hepatology Bark diacron reactive oxygen metabolites (dROM) test business |
| Zdroj: | Journal of Clinical Biochemistry and Nutrition |
| ISSN: | 1880-5086 0912-0009 |
| DOI: | 10.3164/jcbn.20-50 |
| Popis: | We tested oral French maritime pine bark (40 mg)/bilberry fruit extract (90 mg) supplements for intraocular pressure-lowering effects in Japanese subjects with primary open-angle glaucoma. Eighteen subjects (29 eyes) were recruited with intraocular pressure of ≥15 mmHg who used one to three bottles of antiglaucoma medications. After a 2-week observation (period 1), subjects ingested a tablet/day of Sante® Glagenox for 4 weeks (period 2). The mean intraocular pressure (17.2 ± 2.3 mmHg) decreased significantly to 15.7 ± 1.9 mmHg (8.7% reduction) at week 4 (p = 0.0046). The mean morning intraocular pressure (14.1 ± 3.1 mmHg) self-measured using the iCare HOME tonometer during period 1 decreased significantly to 13.3 ± 2.9 mmHg (5.7% reduction) during period 2 (p = 0.0291). Blood redox parameters, diacron reactive oxygen metabolites, biologic antioxidant potential, and sulfhydryl tests were unchanged after 4-week supplementation. Intra-subject comparisons, compared to period 1, showed pooled, self-measured, period-2 intraocular pressures was significantly lower in nine subjects (50%), unchanged in six subjects (33%), and elevated in three subjects (17%), suggesting some non-responders. Four-week supplementation with French maritime pine bark/bilberry fruit extracts can further reduce intraocular pressure even in Japanese patients with controlled primary open-angle glaucoma. Further study should confirm the intraocular pressure-lowering effects and mechanisms of this supplement in glaucoma management. The study was registered in UMIN (ID: UMIN000033200). |
| Databáze: | OpenAIRE |
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