Two-phase scintigraphy with technetium 99m–sestamibi in patients with hyperparathyroidism due to chronic renal failure
| Autor: | M. A. Muros, Fernando Perán, José M. López Ruiz, María Bellón Guardia, Juan Bravo Soto, Mariano Rodríguez-Portillo, Angel Miguel Ramírez Navarro, Jose M. Llamas-Elvira |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Technetium Tc 99m Sestamibi Pathology medicine.medical_specialty Scintigraphy Technetium (99mTc) sestamibi Parathyroid Glands chemistry.chemical_compound stomatognathic system medicine Humans Radionuclide Imaging Retrospective Studies Creatinine Hyperparathyroidism Hyperplasia medicine.diagnostic_test business.industry General Medicine Parathyroid chief cell Middle Aged medicine.disease chemistry Kidney Failure Chronic Female Hyperparathyroidism Secondary Surgery Radiopharmaceuticals business medicine.drug Kidney disease Hormone |
| Zdroj: | The American Journal of Surgery. 193:438-442 |
| ISSN: | 0002-9610 |
| Popis: | Background The objective of the current study was to study different functional and anatomic features of the hyperplastic gland and clinical and biochemical characteristics of renal hyperparathyroidism (HPT) patients and their relationship with the scintigraphic detection of parathyroid glands. Methods A retrospective study was performed of 40 patients with chronic renal failure (CRF) who underwent cervical surgery for HPT. Weight, histology, and localization of hyperplastic glands were recorded. Parathyroid cell proliferation was assessed by percentage of S-phase cells. Double-phase scintigraphy with technetium 99m–sestamibi and serum parathyroid intact hormone (PTHi), creatinine, calcium, and phosphate levels were performed. Results Detection of hyperplastic parathyroid glands by 99m Tc-sestamibi scintigraphy was associated with the weight and inferior localization of the glands. The functionality of the glands as reflected in serum PTHi and phosphorus levels was associated with the number of glands detected. Conclusion Double-phase 99m Tc-sestamibi scintigraphy is of limited usefulness in patients with renal HPT. Detection of hyperplastic parathyroid glands in patients with CRF depends on the weight and inferior localization of the glands. Serum PTHi, phosphorus and creatine levels are associated with the number of glands detected by means of 99m Tc-sestamibi scintigraphy. |
| Databáze: | OpenAIRE |
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