MORPHOLOGICAL CHANGES IN THE ENDOCRINE PANCREAS IN PREGNANT RATS WITH EXPERIMENTAL DIABETES
| Autor: | L. Aerts, F. A. Van Assche, W. Gepts |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism Pregnancy in Diabetics Cell Count Diabetes Mellitus Experimental Muscle hypertrophy Islets of Langerhans Endocrinology Pregnancy Diabetes mellitus Internal medicine medicine Animals Endocrine system business.industry Hyperplasia medicine.disease Rats medicine.anatomical_structure Experimental pathology Female business Pancreas Experimental diabetes |
| Zdroj: | Journal of Endocrinology. 80:175-179 |
| ISSN: | 1479-6805 0022-0795 |
| DOI: | 10.1677/joe.0.0800175 |
| Popis: | This present study has demonstrated that during normal pregnancy in the rat the number of β-cells is increased (hyperplasia) and the volume of the individual β-cells is increased (hypertrophy). During experimental diabetes, however, the endocrine pancreas has an impaired capacity to compensate during pregnancy. In the experimental diabetic pregnant rat the β-cells cannot replicate due to the unfavourable metabolic environment. This could reflect the complications caused by diabetes during human pregnancy. |
| Databáze: | OpenAIRE |
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