Hormone Replacement Effects on Endothelial Function Measured in the Forearm Resistance Artery in Normocholesterolemic and Hypercholesterolemic Postmenopausal Women

Autor: Mikio Tsuda, Koso Ohama, Keigo Nakagawa, Masashi Kimura, Yukihito Higashi, Kazuaki Chayama, Ichiro Kodama, Mitsuhiro Sanada
Rok vydání: 2002
Předmět:
medicine.medical_specialty
medicine.drug_class
Endocrinology
Diabetes and Metabolism
medicine.medical_treatment
Hypercholesterolemia
Clinical Biochemistry
Hyperemia
Medroxyprogesterone Acetate
Peptidyl-Dipeptidase A
Biochemistry
Nitroglycerin
Endocrinology
Forearm
Internal medicine
medicine
Humans
Medroxyprogesterone acetate
Endothelial dysfunction
Reactive hyperemia
Nitrites
Estrogens
Conjugated (USP)
Nitrates
Estradiol
business.industry
Cholesterol
HDL
Estrogen Replacement Therapy
Biochemistry (medical)
Hormone replacement therapy (menopause)
Arteries
Cholesterol
LDL
Middle Aged
medicine.disease
Lipids
Plethysmography
Postmenopause
body regions
Menopause
medicine.anatomical_structure
Estrogen
Vascular resistance
Female
Vascular Resistance
Endothelium
Vascular
business
Blood Flow Velocity
medicine.drug
Zdroj: The Journal of Clinical Endocrinology & Metabolism. 87:4634-4641
ISSN: 1945-7197
0021-972X
Popis: We investigated whether forearm resistance artery endothelial function differed between hypercholesterolemic postmenopausal women (n = 41) and normocholesterolemic postmenopausal women (n = 37), both generally and in terms of effects of long-term hormone replacement therapy (HRT) on endothelial function. Both menopause and hypercholesterolemia are associated with endothelial dysfunction and increased coronary risk. Forearm blood flow (FBF) during reactive hyperemia and after sublingual nitroglycerin (NTG) administration was measured by strain-gauge plethysmography. Treated women received conjugated equine estrogen (0.625 mg) plus medroxyprogesterone acetate (2.5 mg) daily for 6 months. Nitrite/nitrate, angiotensin-converting enzyme, and lipids were measured in serum. FBF during reactive hyperemia as well as serum nitrite/nitrate concentrations were significantly lower in hypercholesterolemic than normocholesterolemic subjects. Increases in the FBF induced by NTG were similar in the two groups. HRT significantly increased estradiol, high-density lipoprotein cholesterol, and serum nitrite/nitrate, while decreasing circulating angiotensin-converting enzyme activity in both groups. Reduction in total and low-density lipoprotein cholesterol was seen only in hypercholesterolemic subjects. After 6 months of HRT, maximal FBF response during reactive hyperemia increased in both groups. Augmentation of this response was greater in hypercholesterolemic than in normocholesterolemic subjects (maximal FBF, 55.4 +/- 11.2 vs. 25.9 +/- 11.5%; P0.05). Changes in the FBF with NTG were not altered by HRT in either group. Long-term HRT augments endothelial function in forearm resistance artery. This beneficial effect is greater in patients with hypercholesterolemia.
Databáze: OpenAIRE
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