Fenoldopam in newborn patients undergoing cardiopulmonary bypass: controlled clinical trial
| Autor: | Vincenzo Vitale, Chiara Giorni, Zaccaria Ricci, Sergio Picardo, Claudio Ronco, Luca Di Chiara, Giulia V. Stazi, Stefano Morelli |
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| Rok vydání: | 2008 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty Sternum Time Factors Fenoldopam Critical Care Renal function Urination law.invention law Internal medicine medicine Cardiopulmonary bypass Humans Infusions Parenteral Prospective Studies Cardiac Surgical Procedures Cardiopulmonary Bypass business.industry Sodium Acute kidney injury Hemodynamics Infant Newborn Perioperative Water-Electrolyte Balance medicine.disease Intensive care unit Respiration Artificial Patient Discharge Cardiac surgery Urodynamics Treatment Outcome Anesthesia Creatinine Dopamine Agonists Coronary care unit Cardiology Potassium Surgery Kidney Diseases Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Interactive cardiovascular and thoracic surgery. 7(6) |
| ISSN: | 1569-9285 |
| Popis: | We determined if low dose fenoldopam in neonates already receiving conventional diuretics improves urine output, fluid balance, acute kidney injury incidence (AKI) and time to extubation. A prospective controlled clinical trial in a pediatric cardiac intensive care unit on 40 neonates undergoing cardiac surgery with cardiopulmonary bypass, excluding simple ventricular septal defect and atrial septal defect. Fenoldopam was infused at a low dose of 0.1 microg/kg/min soon after anesthesia induction and infusion prolonged for 72 h in 20 patients. Twenty neonates with standardized perioperative therapy except fenoldopam administration served as controls. Demographic, hemodynamic, daily urine output, creatinine, creatinine clearance, serum and urinary sodium and potassium were recorded. Inotropic score (IS) was calculated as a surrogate for the degree of hemodynamic impairment. Low dose fenoldopam infusion did not show beneficial effects in renal function. The treatment did not significantly affect IS value, AKI incidence, fluid balance control, time to sternal closure, time to extubation and time to intensive care unit discharge. Low dose fenoldopam in neonates undergoing cardiac surgery with CPB did not produce effects on urine output, fluid balance and AKI incidence. Fenoldopam was well tolerated and did not negatively affect hemodynamics and vasopressor support. |
| Databáze: | OpenAIRE |
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