Evaluation of retinal nerve fiber layer defect using wide-field en-face swept-source OCT images by applying the inner limiting membrane flattening
| Autor: | Hidetoshi Takahashi, Tetsuya Yuasa, Tsutomu Kikawa, Naoko Takada, Seri Takahashi, Koudai Kimura, Akiko Matsumoto, Kazuichi Maruyama, Kazuko Omodaka, Naoki Miura, Toru Nakazawa, Masahiro Akiba |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male Retinal Ganglion Cells Visual acuity genetic structures Eye Diseases Vision Nerve fiber layer Visual Acuity Glaucoma lcsh:Medicine Social Sciences Diagnostic Radiology chemistry.chemical_compound 0302 clinical medicine Nerve Fibers Animal Cells Normal tension glaucoma Medicine and Health Sciences Psychology Low Tension Glaucoma lcsh:Science Tomography Neurons Multidisciplinary Radiology and Imaging Middle Aged Visual field medicine.anatomical_structure Female Sensory Perception medicine.symptom Anatomy Cellular Types Tomography Optical Coherence Optic disc Research Article medicine.medical_specialty Materials science Ganglion Cells Imaging Techniques Ocular Anatomy Research and Analysis Methods Retina Optic Disc 03 medical and health sciences Ocular System Diagnostic Medicine Ophthalmology medicine Humans Aged Reproducibility lcsh:R Reproducibility of Results Biology and Life Sciences Afferent Neurons Retinal Cell Biology medicine.disease eye diseases 030104 developmental biology chemistry Cellular Neuroscience 030221 ophthalmology & optometry Eyes lcsh:Q sense organs Head Neuroscience |
| Zdroj: | PLoS ONE PLoS ONE, Vol 12, Iss 10, p e0185573 (2017) |
| ISSN: | 1932-6203 |
| Popis: | Purpose The assessment of retinal nerve fiber layer defects (RNFLDs) is a useful part of glaucoma care. Here, we obtained en-face images of retinal layers below the inner limiting membrane (ILM) with swept source-optical coherence tomography (SS-OCT), and measured RNFLD angle with new software. Methods This study included 105 eyes of 105 normal tension glaucoma (NTG) patients (age, 59.8 ± 13.2). Exclusion criteria were best-corrected visual acuity 28 mm, non-glaucoma ocular disease, and systemic disease affecting the visual field. We obtained 12 x 9 mm 3D volume scans centered on the macula with SS-OCT (DRI OCT-1, Topcon), and from these scans, created 3 averaged en-face images, each comprising 7 horizontal en-face images (total thickness: 18.2 μm). We labeled these averaged images, according to their depth below the ILM, as en-face images 1 (shallowest), 2 (middle) and 3 (deepest). In each image, a circle was drawn centered on the disc, with a radius of half the distance between the centers of the disc and macula. The investigator marked points where the edge of the RNFLD intersected this circle, and RNFLD angle (RNFLDA) was calculated with new software. Finally, we analyzed the association between RNFLDA, cpRNFLT, weighted RGC count (wrgc) and Humphrey field analyzer (HFA)-measured mean deviation (MD) and hemifield total deviation (TD), both overall and in each hemifield. Results En-face image 2 had the highest interclass reproducibility for measuring RNFLDA (intra-rater intraclass correlation coefficient (ICC): 0.988, inter-rater ICC: 0.962). The correlation coefficients with RNFLDA were: HFA MD, -0.60; superior TD, -0.73; inferior TD, -0.69; overall cpRNFLT, -0.27; superior hemifield cpRNFLT, -0.39; and inferior hemifield cpRNFLT, -0.53 (all p |
| Databáze: | OpenAIRE |
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