Two New Paracetamol/Dioxane Solvates—a System Exhibiting a Reversible Solid‐State Phase Transformation
| Autor: | Ranko M. Vrcelj, E.E.A. Shepherd, David B. Sheen, Alan R. Kennedy, Nathan I.B. Clark, John N. Sherwood |
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| Rok vydání: | 2003 |
| Předmět: |
Chemistry
Molecular Conformation Temperature Solid-state Pharmaceutical Science Crystal structure Crystallography X-Ray Phase Transition law.invention Dioxanes Crystallography Polymorphism (materials science) law Solvents Desolvation Orthorhombic crystal system Crystallization Acetaminophen Monoclinic crystal system |
| Zdroj: | Journal of Pharmaceutical Sciences. 92:2069-2073 |
| ISSN: | 0022-3549 |
| DOI: | 10.1002/jps.10477 |
| Popis: | This work reports on the crystal structures of two dioxane solvates of paracetamol that are true polymorphs. The high temperature phase is an orthorhombic form, space group Pbca, Z = 8, a = 12.6078(3) A, b = 12.1129(2) A, c = 13.4138(3) A, V = 2048.52(7) A 3 , (at 295 K) and the low temperature form is monoclinic, space group P2 1 /c, Z = 4, a = 12.325(6) A, b = 11.965(4) A, c = 13.384(6) A, β = 92.01°, V = 1972.6(14)A 3 (at 123 K). The structures of these polymorphs are described as is the interrelationship between the two structures. In addition to the structural interrelationship, it is shown that the two forms undergo a reversible phase transformation. Desolvation of either form generates the stable monoclinic phase of paracetamol. © 2003 Wiley‐Liss, Inc. and the American Pharmacists Association J Pharm Sci 92:2069–2073, 2003 |
| Databáze: | OpenAIRE |
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