Cubic phase nanoparticles for sustained release of ibuprofen formulation characterization and enhanced bioavailability study
| Autor: | Xin Pan, Ge Li, Zhiwen Yang, Linghui Dian, Xintian Huang, Bao Chen, Zhefei Guo, Feng Li, Xinsheng Peng, Xuan Shi, Zhouhua Wang, Guilan Quan, Chuanbin Wu |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Materials science
Stereochemistry oral drug delivery Biophysics Pharmaceutical Science Nanoparticle Biological Availability Bioengineering Ibuprofen Biomaterials Differential scanning calorimetry Dogs International Journal of Nanomedicine Drug Discovery medicine Animals Particle Size Original Research Drug Carriers Aqueous solution organic chemicals Organic Chemistry General Medicine Bioavailability cubic nanoparticles Area Under Curve Delayed-Action Preparations Drug delivery Nanoparticles Female Particle size Drug carrier bioavailability Nuclear chemistry medicine.drug |
| Zdroj: | International Journal of Nanomedicine |
| ISSN: | 1178-2013 |
| Popis: | Linghui Dian,1,2,* Zhiwen Yang,3,* Feng Li,1 Zhouhua Wang,1 Xin Pan,1 Xinsheng Peng,2 Xintian Huang,1 Zhefei Guo,1 Guilan Quan,1 Xuan Shi,1 Bao Chen,1 Ge Li,4 Chuanbin Wu1,41School of Pharmaceutical Sciences, Sun Yat-Sen University, University Town, Guangzhou, People’s Republic of China; 2School of Pharmaceutical Sciences, Guangdong Medical College, Dongguan, People’s Republic of China; 3Department of Gastroenterology, Songjiang Branch of the Affiliated First People’s Hospital of Shanghai Jiaotong University, Shanghai, People’s Republic of China; 4Guangdong Research Center for Drug Delivery Systems, Guangzhou, People’s Republic of China*These authors contributed equally to this workAbstract: In order to improve the oral bioavailability of ibuprofen, ibuprofen-loaded cubic nanoparticles were prepared as a delivery system for aqueous formulations. The cubic inner structure was verified by cryogenic transmission electron microscopy. With an encapsulation efficiency greater than 85%, the ibuprofen-loaded cubic nanoparticles had a narrow size distribution around a mean size of 238 nm. Differential scanning calorimetry and X-ray diffraction determined that ibuprofen was in an amorphous and molecular form within the lipid matrix. The in vitro release of ibuprofen from cubic nanoparticles was greater than 80% at 24 hours, showing sustained characteristics. The pharmacokinetic study in beagle dogs showed improved absorption of ibuprofen from cubic nanoparticles compared to that of pure ibuprofen, with evidence of a longer half-life and a relative oral bioavailability of 222% (P < 0.05). The ibuprofen-loaded cubic nanoparticles provide a promising carrier candidate with an efficient drug delivery for therapeutic treatment.Keywords: ibuprofen, cubic nanoparticles, oral drug delivery, bioavailability |
| Databáze: | OpenAIRE |
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