Phenotypic distinctiveness of Staphylococcus aureus strains associated with toxic shock syndrome
| Autor: | Amalia Franco-Buff, M L Vasil, David W. Lawellin, Jim Todd |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Staphylococcus aureus
genetic structures Immunology Enterotoxin Biology medicine.disease_cause Staphylococcal infections Microbiology Hemolysis Enterotoxins Plasmid Bacteriocin Bacterial Proteins medicine Humans Toxic shock syndrome Staphylococcal Infections medicine.disease bacterial infections and mycoses Shock Septic Infectious Diseases Phenotype Parasitology Exotoxin Peptide Hydrolases Plasmids Research Article |
| Zdroj: | Infection and immunity. 45(2) |
| ISSN: | 0019-9567 |
| Popis: | Twenty Staphylococcus aureus strains from patients with toxic shock syndrome (TSS) and 20 from control patients (non-TSS) with infection but no clinical evidence of TSS were compared phenotypically in a collaborative, blinded, randomized study. TSS strains were significantly (P less than 0.05) more likely than non-TSS strains to produce various previously described but related toxic shock-associated proteins (pyrogenic exotoxin C, enterotoxin F, and TSS marker protein), as well as differing in other distinctive phenotypic characteristics, such as hemolysis, bacteriocin susceptibility, arsenate resistance, pigment production, and casein proteolysis. TSS strains were significantly less likely to carry plasmids than control strains. A combination of two variables--proteolysis and toxic shock-associated protein production--statistically accounted for all other phenotypic variations between TSS and non-TSS strains. Only proteolysis covaried with all other significant variables, suggesting a primary role in the phenotypic distinctiveness of TSS S. aureus strains and possibly in the pathogenesis of TSS. |
| Databáze: | OpenAIRE |
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