HAPLOIDENTICAL HEMATOPOIETIC STEM CELL TRANSPLANTATION IN CHILD HEMATOLOGIC MALIGNANCIES WITH G-CSF-MOBILIZED MARROW GRAFTS WITHOUT T-CELL DEPLETION: A Single-Center Report of 45 Cases

Autor:	Zi-Kuan Guo, Mei Xue, Liang-Ding Hu, Zhi-Dong Wang, Heng-Xiang Wang, Jing Liu, Lian-Ning Duan, Ling Zhu, Hong-Min Yan
Rok vydání:	2009
Předmět:	Male Oncology medicine.medical_specialty Adolescent medicine.medical_treatment Hematopoietic stem cell transplantation Single Center Disease-Free Survival HLA Antigens Cause of Death Internal medicine Granulocyte Colony-Stimulating Factor medicine Humans Transplantation Homologous Child Survival rate Bone Marrow Transplantation business.industry Hematopoietic Stem Cell Transplantation Infant Hematology medicine.disease Hematopoietic Stem Cell Mobilization Hematopoiesis Transplantation Leukemia Haematopoiesis surgical procedures operative medicine.anatomical_structure Graft-versus-host disease Haplotypes Child Preschool Hematologic Neoplasms Histocompatibility Pediatrics Perinatology and Child Health Immunology Female Bone marrow business
Zdroj:	Pediatric Hematology and Oncology. 26:119-128
ISSN:	1521-0669 0888-0018
Popis:	In this report, the authors describe a protocol for haploidentical bone marrow transplantation in children who received G-CSF-mobilized bone marrow grafts without T-cell depletion from HLA-mismatched parents. Forty-two of 45 patients achieved complete donor hematopoietic engraftment; the medium time for neutrophil and platelet recovery was 17 and 19 days, respectively. Three died of early transplantation-associated complications; other causes of death included relapse (11 cases), fungal pneumonia (5), and acute graft-versus-host disease (2). The total disease-free survival rate longer than 2 years was 53.3%. These data suggest that haploidentical hematopoietic transplantation is an alterative strategy for children who lack immediate access to HLA-matched sources.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12d8f89e9e8e0db0e9a77e1f4c777dab https://doi.org/10.1080/08880010902772208 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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