Inhibition of Tendon Cell Proliferation and Matrix Glycosaminoglycan Synthesis by Non-Steroidal Anti-Inflammatory Drugs in vitro
| Autor: | Graham P. Riley, Brian L. Hazleman, R L Harrall, Malcolm Cox, S. Clements |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Adult
Male musculoskeletal diseases medicine.medical_specialty Diclofenac Indomethacin Pharmacology Tendons Glycosaminoglycan Extracellular matrix 03 medical and health sciences Naproxen 0302 clinical medicine Tendon cell In vivo Culture Techniques medicine Humans Aged Glycosaminoglycans Wound Healing 030222 orthopedics Transplantation Cell growth business.industry Anti-Inflammatory Agents Non-Steroidal 030229 sport sciences Middle Aged musculoskeletal system Tendon Surgery medicine.anatomical_structure Female Patella business Cell Division medicine.drug |
| Zdroj: | Journal of Hand Surgery. 26:224-228 |
| ISSN: | 0266-7681 |
| DOI: | 10.1054/jhsb.2001.0560 |
| Popis: | The purpose of this study was to investigate the effects of some commonly used non-steroidal anti-inflammatory drugs (NSAIDs) on human tendon. Explants of human digital flexor and patella tendons were cultured in medium containing pharmacological concentrations of NSAIDs. Cell proliferation was measured by incorporation of3H-thymidine and glycosaminoglycan synthesis was measured by incorporation of35S-Sulphate. Diclofenac and aceclofenac had no significant effect either on tendon cell proliferation or glycosaminoglycan synthesis. Indomethacin and naproxen inhibited cell proliferation in patella tendons and inhibited glycosaminoglycan synthesis in both digital flexor and patella tendons. If applicable to the in vivo situation, these NSAIDs should be used with caution in the treatment of pain after tendon injury and surgery. |
| Databáze: | OpenAIRE |
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